摘要
目的:观察奥氮平治疗精神分裂症患者认知功能的疗效及安全性。方法:将100例首发精神分裂症患者根据治疗方案不同分为对照组和观察组,每组各50例。对照组予以利培酮治疗,观察组予以奥氮平治疗,疗程均为8周;治疗前后行阳性与阴性症状量表(PANSS)评分以评估精神症状,行认知功能成套测验系统(MCCB)以评估认知功能;并对两组治疗前后体重指数(BMI)、糖脂代谢指标及血清脂联素(APN)、瘦素水平进行对比分析。结果:治疗后,两组PANSS评分相比治疗前均明显降低(P<0.05),组间比较差异无统计学意义(P>0.05)。治疗后,观察组MCCB测试(连线测试、操作速度、工作记忆)改善程度均明显优于对照组(P<0.05)。治疗后,两组BMI、空腹血糖、总胆固醇、三酰甘油、低密度脂蛋白水平比治疗前明显增高(P<0.05),且观察组增高程度小于对照组(P<0.05)。治疗后,两组血清APN水平明显降低(P<0.05),瘦素水平明显增高(P<0.05),且观察组的变化程度小于对照组(P<0.05)。结论:奥氮平治疗精神分裂症的疗效与利培酮相当,但其对患者认知功能的改善效果更好,且对体重、糖脂代谢及APN、瘦素水平的影响较小,安全性较高。
Objective:To observe the efficacy and safety of olanzapine in the treatment of cognitive function in patients with schizophrenia.Methods:100 patients with first-episode schizophrenia were divided into the control group(n=50)and the observation group(n=50)according to different treatment schemes.The control group treated with risperidone,and the observation group treated with olannzapine for 8 weeks.The positive and negative sympotom scale(PANSS)before and after treatment was used to evaluate psychiatric symptoms.Also,the MATRICS Consensus Cognitive Battery(MCCB)system was adopted to assess the cognitive function.Moreover,the body mass index(BMI),glycolipid metabolism index,the levels of serum adiponectin and leptin between the two groups before and after treatment were compared and analyzed.Results:After treatment,the PANSS scores of the two groups were significantly lower than those before treatment(P<0.05),and there was no significant difference between the two groups(P>0.05).After treatment,the improvement of MCCB system(connection testing,operation speed,working memory)in the observation group was significantly better than that in the control group(P<0.05).The BMI,fasting blood glucose,total cholesterol,triacylglycerol and low density lipoprotein cholesterol of the two groups after treatment were significantly higher than those before treatment(P<0.05),and the degree of increase in the observation group was lower than that in the control group(P<0.05).Additionally,the levels of serum adiponectin in the two groups were significantly reduced(P<0.05)and the level of leptin was significantly increased(P<0.05),and the degree of change in the observation group was smaller than that in the control(P<0.05).Conclusion:The olanzapine is as effective as risperidone in the treatment of schizophrenia,but it has a better effect on the improvement of cognitive function and has little impact on body weight,glycolipid metabolism,APN and leptin,with a higher safety.
作者
张永超
李建军
ZHANG Yong-chao;LI Jian-jun(Xiangyang Anding Hospital,Xiangyang 441050;Xiangyang Central Hospital,Xiangyang 441021,Hubei,China)
出处
《川北医学院学报》
CAS
2020年第6期990-993,共4页
Journal of North Sichuan Medical College
基金
湖北省自然科学基金(2017CFB723)。
关键词
精神分裂症
奥氮平
认知功能
糖脂代谢
脂肪细胞因子
Schizophrenia
Olanzapine
Cognitive function
Glycolipid metabolism
Adipocytokines
