摘要
目的探讨上海市名中医孙世道教授治疗特应性皮炎(AD)的用药经验。方法收集2015年1月—2018年1月上海中医药大学附属曙光医院孙世道教授特需门诊治疗AD患者的中药处方,基于中医传承辅助系统软件,采用关联规则算法、复杂系统熵聚类等无监督的数据挖掘方法,分析孙世道教授治疗AD的组方特点和用药规律。结果本研究共纳入中药处方274首,涉及药物189味,使用频次在70次以上的药物有丹皮、苦参、知母、白鲜皮、黄芩、玄参、土茯苓等共18味,以寒性、苦味、肝经药物使用频次最高。获得置信度>0.98的药物组合17个,提取核心药物组合8个,挖掘潜在治疗新方4首。结论孙世道教授治疗AD以清热、凉血、除湿为主,辅以健脾益气、祛风止痒。
Objective To explore the medication experience of Professor Sun Shidao of Shanghai famous traditional Chinese medicine physician in the treatment of atopic dermatitis(AD).Methods The prescriptions treated with AD of Professor Sun Shidao in Special Outpatient Department of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2015 to January 2018 were collected.Based on the software of traditional Chinese medicine inheritance support system,unsupervised data mining methods such as association rule algorithm and entropy clustering of complex system were adopted.The prescription characteristics and medication rules of Professor Sun Shidao in the treatment of AD were analyzed.Results A total of 274 prescriptions were included in this study,involving 189 kinds of medicine.The drugs used more than 70 times included 18 kinds of medicine such as Cortex Moutan Radicis,Radix Sophorae Flavescentis,Rhizoma Anemarrhenae,Cortex Dictamni,Radix Scutellariae,Radix Scrophulariae,Rhizoma Smilacis Glabrae.The character of highest frequency used medicine mainly concentrated in cold,bitter,and liver channel of traditional Chinese medicine meridian.Seventeen drug combinations with a confidence level greater than 0.98 were obtained,eight core drug combinations were extracted,and four potential new therapeutic prescriptions were mined.Conclusion Professor Sun Shidao treats AD mainly by clearing heat,cooling blood and removing dampness,supplemented by invigorating spleen and benefiting qi,dispelling pathogenic wind and relieving itching.
作者
马欣
张慧敏
丁佩军
MA Xin;ZHANG Huimin;DING Peijun(Department of Dermatology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中国医药导报》
CAS
2020年第36期146-149,共4页
China Medical Herald
基金
上海市卫生健康委员会名中医学术经验研究工作室建设项目(SHGZS-2017020)
上海市卫生健康委员会海派中医流派传承人才培养项目(LPRC2017041)
上海市卫生健康委员会临床研究专项项目(20184Y0020)。
关键词
特应性皮炎
孙世道
用药规律
数据挖掘
中医传承辅助系统
Atopic dermatitis
Sun Shidao
Medication rules
Data mining
Traditional Chinese medicine inheritance support system
