摘要
目的:分析妊娠期孕妇血清转铁蛋白(TRF)、总铁结合力(TIBC)与妊娠期代谢综合征(GMS)的相关性。方法:选取2018年2月—2020年1月于本院产科定期产前检查并住院分娩的GMS患者72例(观察组),同期正常妊娠孕妇80例为对照组。收集两组孕周、孕前体质指数、基础收缩压、基础舒张压、空腹血糖、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等。免疫比浊法检测血清中TRF;全自动生化分析仪检测血清TIBC水平。多因素logistic回归分析发生GMS的影响因素;受试者工作特征曲线(ROC)分析TRF、TIBC对发生GMS的预测价值。结果:观察组血清TRF(411.72±51.46 mg/dl)、TIBC(92.46±10.83μmol/L)均高于对照组(278.65±36.38 mg/dl、61.58±9.72μmol/L)(P<0.05)。多因素分析,孕周、孕前BMI、基础收缩压、基础舒张压、TC、TG、LDL-C等不是影响GMS的因素(P>0.05),TRF、TIBC水平偏高是发生GMS的危险因素(P<0.05)。ROC分析,TRF、TIBC预测妊娠期发生GMS的曲线下面积(AUC)分别为0.839(95%CI:0.757-0.921)、0.815(95%CI:0.730-0.900)。结论:TRF、TIBC在GMS孕妇血清中水平升高,是孕妇发生GMS的危险因素,对GMS有一定预测价值,可能作为潜在的诊断妊娠期孕妇发生GMS的标志物。
Objective:To analyze the relationship between serum transferrin(TRF)level and total iron binding capacity(TIBC)of women and their gestational metabolic syndrome(GMS)occurance.Methods:72 pregnant women with GMS were selected in experimental group and another 80 normal pregnant women were selected in control group from February 2018 to January 2020.The general data,such as gestational weeks,pre pregnancy BMI,basal systolic blood pressure,basal diastolic blood pressure,fasting blood glucose,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)of women in both groups were collected.The level of serum TRF was detected by immunoturbidimetry,and the level of serum TIBC was detected by automatic biochemical analyzer.Multivariate Logistic regression analysis was used to analyze the influencing factors of GMS occurance,and receiver operating characteristic curve(ROC)was used to analyze the value of TRF and TIBC expression levels for predicting GMS of pregnant women.Results:The serum levels of TRF(411.72±51.46 mg/dL)and TIBC(92.46±10.83 mol/L)of women in the experimental group were significant higher than those(278.65±36.38 mg/dL and 61.58±9.72 mol/L)of women in the control group(P<0.05).Multi-factor analysis had showed that gestational weeks,pre-pregnancy BMI,basal systolic blood pressure,basal diastolic blood pressure,TC,TG and ldl-c were not the influencing factors of GMS(P>0.05),but the high levels of TRF and TIBC were the risk factors of GMS(P<0.05).ROC analysis showed that the AUC of TRF level and TIBC level for predicting GMS during pregnancy was 0.839(95%CI:0.757-0.921)and 0.815(95%CI:0.730-0.900),respectively.Conclusion:The levels of serum TRF and TIBC of pregnant women with GMS increase,and which are the risk factors of GMS.The levels of serum TRF and TIBC have certain value for predicting GMS,which may be used as potential markers for diagnosing GMS of pregnant women.
作者
周丽
孟文颖
ZHOU Li;MENG Wenying(Tongzhou District Maternal and Child Health Care Hospital, Beijing, 101100)
出处
《中国计划生育学杂志》
2020年第12期2098-2101,共4页
Chinese Journal of Family Planning
关键词
妊娠期代谢综合征
转铁蛋白
总铁结合力
预测价值
Gestational metabolic syndrome
Transferrin
Total iron binding capacity
Predictive value
