摘要
羟基磷灰石(Hydroxyapatite,HAP)是人体骨骼及牙齿的主要无机成分,具有优良的生物相容性和生物活性,常被用作骨骼的替代材料,在生物医学、涂层材料、污水处理等领域也得到广泛应用。相关研究表明,HAP纳米粒子及基于HAP的纳米复合材料均可以选择性抑制癌细胞生长,其抗肿瘤特性引发众多学者关注。当羟基磷灰石的尺寸达到纳米级别时,其可表现出独特的性能。与传统的HAP粒子相比,纳米级HAP具有高比表面积、高表面能、靶向性等特性,同时其表面粗糙度高、亲和性强,更易吸附蛋白,表现出更佳的生物相容性。但普通纳米羟基磷灰石不稳定,在体内易发生聚沉,从而造成超粒径大、分布不均匀等问题,在临床应用上仍存在着较大障碍,制备HAP纳米复合体系可提高其在体内的适应性。综合国内外相关研究报道介绍了HAP粒子的结构和性质及其在癌症治疗方面的作用机制和特点,并对基于HAP纳米粒子的复合物(HAP复合支架、交联技术的HAP纳米复合物、层层自组装HAP胶囊、杂化型HAP纳米粒子、主动靶向型HAP纳米复合物)在癌症治疗中的应用进行综述。同时对目前纳米HAP应用于癌症治疗中存在的问题进行了分析,并展望了其未来的发展趋势,以期为制备达到临床使用要求的集肿瘤诊断、治疗及术后修复为一体的新的治疗体系提供参考。
Hydroxyapatite(HAP)is the main inorganic component of human bones and teeth.With the excellent biocompatibility and bioactivity,it is widely used as a substitute for bone,and also widely used in biomedicine,coating materials,sewage treatment and other fields.Relevant studies have shown that HAP nanoparticles and HAP based nanocomposites can selectively inhibit the growth of cancer cells,and their anti-tumor properties have attracted many scholars attention.Compared with traditional HAP particles,nano HAP has high specific surface area,high surface energy and targeting property.At the same time,it has high surface roughness and strong affinity,so it is easier to adsorb protein and shows better biocompatibility.However,the conventional nano hydroxyapatite is unstable and easy to agglomerate in vivo,which leads to the problems of large particle size and uneven distribution.There are still great obstacles in clinical application.The preparation of HAP nanocomposite system can improve its adaptability in vivo.The structure and properties of HAP particles,as well as the mechanism and characteristics of HAP particles in cancer treatment were introduced.The application of HAP nanoparticles based complexes in cancer treatment,including HAP composite scaffold,HAP nanocomposites by cross-linking technology,layer by layer self-assembly HAP capsules,hybrid HAP nanoparticles and active targeting HAP nanocomposites,were reviewed.At the same time,the existing problems in the application of nano HAP in cancer treatment were analyzed,and its future development trend was prospected,so as to provide a reference for the preparation of a new treatment system integrating tumor diagnosis,treatment and postoperative repair.
作者
申欣
庞宇
孟昭旭
廉鹤
SHEN Xin;PANG Yu;MENG Zhaoxu;LIAN He(School of Medical Devices,Shenyang Pharmaceutical University,Benxi 117004,China;School of Pharmacy,Shenyang Pharmaceutical University,Benxi 117004,China)
出处
《材料导报》
EI
CAS
CSCD
北大核心
2020年第S02期88-90,共3页
Materials Reports
基金
国家自然科学基金(81503020,31600764)
辽宁省教育厅科学研究经费项目(2019LJC04)
辽宁省自然科学基金指导计划(2019-ZD-0459)
沈阳药科大学大学生创新创业训练计划项目(202010163026)。
