摘要
目的:分析上海市长宁区1973—2013年女性子宫内膜癌发病率及死亡率的分布特征及时间变化趋势。方法:根据1973—2013年上海市长宁区子宫内膜癌发病及死亡登记资料,计算粗发病率及粗死亡率,以及世界人口标化的发病率和死亡率(简称世标率)。采用Joinpoint软件对女性子宫内膜癌的发病率进行时间趋势分析,计算其年度变化百分比和平均年度变化百分比。结果:1973—2013年,上海市长宁区女性子宫内膜癌发病人数805例,粗发病率为7.50/10万,世标发病率为4.97/10万;死亡人数为148例,粗死亡率为1.38/10万,世标死亡率为0.76/10万。通过Joinpoint模型进行发病率的时间趋势分析,发现长宁区女性子宫内膜癌的发病率在1973—2013年呈上升趋势,其中以1973—2007年子宫内膜癌发病率升高有统计学意义,年度变化百分比及95%可信区间为4.2%(3.0%~5.5%),平均年度变化百分比及其95%可信区间为3.0%(1.3%~4.8%)。结论:过去41年,上海市长宁区女性居民子宫内膜癌患者死亡率上升缓慢,但发病率有显著升高趋势。
Objective:To analyze the incidence and mortality rates of endometrial cancer in the Changning District of Shanghai from 1973 to 2013.Methods:Using the registration data of incidence and mortality of endometrial cancer in the Changning District of Shanghai,the crude as well as the age-standardized rates by world standard population of incidence and mortality for endometrial cancer were calculated,respectively.The Joinpoint regression analysis was utilized to estimate the time trend of the endometrial cancer incidence rate and calculate the annual percent change(APC)and average annual percent change(AAPC)in women.Results:From 1973 to 2013,a total of 805 incident cases and 148 deaths were registered in the Changning District,Shanghai.The crude incidence and mortality rates were 7.50 and 1.38 per 100000,while the age-standardized incidence and mortality rates were 4.97 and 0.76 per 100000,respectively.An ascending trend of endometrial cancer incidence from 1973 to 2013 was detected with an AAPC(95%CI)of 3.0%(1.3%-4.8%),and a significant upward trend with the APC(95%CI)of 4.2%(3.0%-5.5%)was observed from 1973 to 2007.Conclusion:The ascending trends of incidence and mortality of endometrial cancer were found in the Changning District of Shanghai during past 41 years.
作者
计晓薇
王洁
姜玉
蒋宇飞
李卓颖
张云
沈秋明
吴婳
夏庆华
赵文穗
项永兵
JI Xiaowei;WANG Jie;JIANG Yu;JIANG Yufei;LI Zhuoying;ZHANG Yun;SHEN Qiuming;WU Hua;XIA Qinghua;ZHAO Wenshui;XIANG Yongbing(School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;State Key Laboratory of Oncogenes and Related Genes&Department of Epidemiology,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China;Shanghai Changning District Center for Disease Control and Prevention,Shanghai 200051,China)
出处
《肿瘤》
CAS
CSCD
北大核心
2020年第11期741-747,共7页
Tumor
基金
国家重点研发计划项目(编号:2016YFC1302503)。
关键词
子宫内膜肿瘤
发病率
死亡率
趋势分析
上海
Endometrial neoplasms
Incidence
Mortality
Time trend analysis
Shanghai
