摘要
目的分析不同剂量他汀类药物短期治疗后的降脂效果和不良反应。方法选择2018年4月—2019年11月期间我院收治的高胆固醇血症患者的74例,根据患者所实施的阿托伐他汀用药剂量将其分为10 mg组和20 mg组,每组37例。两组患者均应用阿托伐他汀进行治疗,其中10 mg组患者剂量10 mg/次,1次/d;20 mg组患者剂量20mg/次,1次/d。两组患者均治疗1周时间。结果两组患者治疗前的TC、TG、LDL-C、HDL-C水平比较,无明显差异(P>0.05);治疗1周后,两组患者的TC、TG、LDL-C水平,均有显著降低,且20 mg组均低于10 mg组患者,比较差异具有统计学意义(P<0.05);而HDL-C水平,两组均有显著升高,且20 mg组高于10 mg组患者,比较差异具有统计学意义(P<0.05)。不同剂量组患者在治疗期间出现的不良反应发生率,比较无明显差异(P>0.05)。结论不同剂量的阿托伐他汀均能够获得良好的短期降脂效果,但相比10 mg/d的剂量,20 mg/d的剂量阿托伐他汀短期治疗降脂效果更佳显著,但两种剂量用药的不良反应均较少,且无明显差异,20 mg/d的阿托伐他汀可以作为临床降脂治疗的首选方案。
Objective To explore the effect and side effect of different dosage of statins after short-term treatment.Methods 74 patients with hypercholesterolemia selected the period from April 2018 to November 2019.According to the dosage of atorvastatin,they were divided into 10 mg group and 20 mg group,37 cases in each group.The dose of 10 mg group was 10 mg/time,once a day;the dose of 20 mg group was 20 mg/time,once a day.Treatment for 1 week.Results There was no difference in the levels of TC,TG,LDL-C and HDL-C before treatment(P>0.05);after one week of treatment,all the patients’TC,TG and LDL-C levels in the 20 mg group were lower than those in the 10 mg group,and the difference was statistically significant(P<0.05).The HDL-C levels in both groups were significantly increased,and 20 mg group was higher than 10 mg group,(P<0.05).There was no difference in the incidence of adverse effects of defecation between different dose groups(P>0.05).Conclusion Different doses of atorvastatin can achieve a good short-term lipid-lowering effect,the 20 mg/d dosage period treatment is more significant,but the adverse reactions of the two doses are less,20 mg/d atorvastatin can be used as the first choice of clinical lipid-lowering treatment.
作者
陈新华
罗时梅
CHEN Xinhua;LUO Shimei(Pharmacy Department,Gaochun Nanjing Hospital of Traditional Chinese Medicine,Nanjing Jiangsu 211300,China)
出处
《中国卫生标准管理》
2020年第24期120-123,共4页
China Health Standard Management
关键词
不同剂量
他汀类药物
阿托伐他汀
短期治疗
降脂效果
不良反应
different doses
statins
atorvastatin
short-term treatment
lipid-lowering effect
adverse reactions
