摘要
目的探讨急性脑梗死患者血清脂蛋白(a)和纤维蛋白原与颈动脉粥样硬化的相关性。方法选取2018年1月~2020年1月在我院神经内科住院的200例急性脑梗死患者为观察组,同时收集100例同期门诊健康体检者为对照组。比较两组血清脂蛋白(a)和纤维蛋白原与颈动脉粥样硬化的关系、两组颈动脉IMT、血清脂蛋白(a)和纤维蛋白原值。结果两组的颈动脉IMT值、血清脂蛋白(a)和纤维蛋白原水平比较,差异有统计学意义(P<0.05);观察组分为非进展性及进展性卒中患者,在比较血清脂蛋白(a)和纤维蛋白原水平上,相较于非进展性卒中者,进展性卒中水平和其比较,差异有统计学意义(P<0.05);脑梗死患者的血清脂蛋白(a)和纤维蛋白原水平会随着动脉粥样硬化严重程度的升高而上升,差异有统计学意义(P<0.05),说明彼此间呈正相关。结论针对神经内科住院的急性脑梗死患者,血清脂蛋白(a)和纤维蛋白原参与其发生发展,密切关联着患者的病情,还可改善患者的生活质量,具有临床应用价值。
Objective To explore the correlation between serum lipoprotein(a),fibrinogen and carotid atherosclerosis in patients with acute cerebral infarction(ACI).Methods Patients with ACI admitted to the department of neurology of our hospital from January 2018 to January 2020 were selected and divided into the observation group(n=200),and outpatients with physical examination at the same time were collected as the control group(n=100).The correlation between serum lipoprotein(a),fibrinogen and carotid atherosclerosis in the two groups,as well as the values of carotid IMT,serum lipoprotein(a)and fibrinogen were compared between the two groups.Results The values of carotid IMT,serum lipoprotein(a)and fibrinogen levels of the two groups were all decreased,and there were significant differences between the two groups(P<0.05).The observation group was divided into the non-progressive stroke patients and progressive stroke patients.Compared with the non-progressive stroke patients,there were significant differences in the progressive level and its contrast of serum lipoprotein(a)and fibrinogen levels in the progressive stroke patients(P<0.05).The levels of serum lipoprotein(a)and fibrinogen in patients with cerebral infarction would increase with the rise of atherosclerosis severity,and the difference was significant(P<0.05),indicating that there was a positive correlation between them.Conclusion For patients with ACI admitted to the department of neurology,serum lipoprotein(a)and fibrinogen are involved in its onset and development,which are closely related to the patient’s condition and may improve the quality of life of patients.Therefore,there is clinical application value.
作者
邹永周
ZOU Yongzhou(Department of Neurology,Jingdezhen First People's Hospital in Jiangxi Province,Jingdezhen333000,China)
出处
《中国现代医生》
2020年第32期49-51,55,共4页
China Modern Doctor
基金
江西省景德镇市科技计划项目(20181SFZC011)。
