摘要
急性肝衰竭是一种严重而复杂的肝脏疾病,短期病死率高,其发病机制尚未明确,亦缺乏特效药物。动物模型制备对于深层次揭露急性肝衰竭发病和药物疗效机制具有重要意义,而实验动物和制备方式的选择是研究能否有效实施的关键保障。总结了近年来常用及新型急性肝衰竭动物模型和相应制备方式,大致将急性肝衰竭动物模型分为以下四大类:化学药物模型、手术模型、感染模型及其他模型。同时,结合Terblanche和Hickman等肝衰竭模型评价标准对上述模型进行评价,希望能为此病的基础研究提供模型选择及评价参考。
Acute liver failure is a serious and complex liver disease with a high short-term mortality rate.Its pathogenesis remains unknown and there is still a lack of effective drugs.Animal models play an important role in further revealing the pathogenesis of acute liver failure and the therapeutic mechanism of drugs,and the selection of experimental animals and preparation methods is the key to the effective implementation of research.This article summarizes the commonly used and new animal models of acute liver failure in recent years and the corresponding preparation methods and divides the animal models of acute liver failure into following four categories:chemical drug model,surgical model,infection model,and other models.Meanwhile,the above models are evaluated based on Terblanche and Hickman evaluation criteria for liver failure models,hoping to provide a reference for model selection and evaluation in basic research on this disease.
作者
龙富立
林镛
彭子明
冯逢
张建玲
毛德文
韦艾凌
LONG Fuli;LIN Yong;PENG Ziming;FENG Feng;ZHANG Jianling;MAO Dewen;WEI Ailing(Graduate School,Guangxi University of Chinese Medicine,Nanning 530200,China;Department of Hepatology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China;College of Adult Education,Guangxi University of Chinese Medicine,Nanning 530001,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2021年第1期204-208,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金课题(81760844,81960841)
国家科技重大专项(2018ZX10725505-001-011)
广西科技计划项目(桂科AD17129001)
广西中医基础研究重点实验室(17-259-49-04)
广西一流学科(中医学)建设开放课题(2019XK023)
广西中医药大学研究生教育创新计划项目(YCSY2018026,BS006)
广西高校中青年教师基础能力提升项目(P18011)。
