摘要
腹膜透析相关性腹膜炎(peritoneal dialysis-associated peritonitis,PDAP)是导致患者退出腹膜透析的主要原因,其中真菌性腹膜炎(fungal peritonitis,FP)虽然在PDAP中占比少,但其治愈率低,由其导致的技术失败率及PDAP相关死亡率高。然而,至今尚缺乏统一的FP预防及治疗方案。预防FP的药物主要包括制霉菌素与氟康唑,但其用药时机尚未确定。治疗FP主要包括拔除导管和抗真菌药物治疗两个方面。然而,尽管在大多数情况下需要拔除导管,但拔除导管的最佳时间仍然未知。本文结合近年来的重要临床研究,对腹膜透析相关性FP的预防及治疗进行综述。
Peritoneal dialysis-associated peritonitis(PDAP)is the main reason that causes patients to withdraw from peritoneal dialysis.Although fungal peritonitis(FP)accounted for less in PDAP,it had the lowest cure rate,the highest technical failure rate and PDAP-related mortality.However,there is still no unified FP prevention and treatment program.The drugs to prevent FP mainly include nystatin and fluconazole,but the timing of their use has not been determined.Treatment of FP mainly includes catheter removal and antifungal therapy.However,although catheter removal is required in most cases,the optimal time for catheter removal is still unknown.In this paper,the prevention and treatment of peritoneal dialysis-related FP was reviewed in combination with recent important clinical studies.
作者
李忻阳
张禹
罗佩婷
王杨威
崔文鹏
Li Xinyang;Zhang Yu;Luo Peiting;Wang Yangwei;Cui Wenpeng(Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China)
出处
《中华肾病研究电子杂志》
2020年第6期260-263,共4页
Chinese Journal of Kidney Disease Investigation（Electronic Edition）
基金
吉林省卫生厅项目(2017Q024、2018FP031)。
关键词
真菌性腹膜炎
腹膜透析
预防
治疗
Fungal peritonitis
Peritoneal dialysis
Prevention
Treatment
