摘要
目的探讨影响食管早期浸润鳞癌患者术后生存的关键因素。方法在分析本实验室所建立的1973年至2019年食管癌、贲门癌患者大样本资料库的基础上,通过对其中一家三甲医院3050例食管早期浸润鳞癌患者的不同临床病理特征及生存情况进行对比分析,并将这些患者的确诊年代分为4个时间段(1974年至1986年、1987年至1997年、1998年至2008年、2009年至2019年),采用寿命表法、Kaplan-Meier法和Cox回归模型分析4个不同时间段影响食管早期浸润鳞癌患者预后的主要因素。结果3050例食管早期浸润鳞癌患者中,4个时间段的食管早期浸润鳞癌的检出率逐段显著升高(χ^2=1793.785,P<0.001),1973年至1986年31例(0.52%),1987年至1997年165例(0.80%),1998年至2008年949例(3.39%),2009年至2019年1905例(7.98%)。Cox回归模型分析示年龄是食管早期浸润鳞癌预后的独立危险因素。结论1973年至2019年食管早期浸润鳞癌的检出率逐渐升高,年龄是早期食管浸润鳞癌预后的独立影响因素。
Objective To study the key factors affecting the survival of patients with early esophageal squamous cell cancer.Methods At the basis of the database of esophageal cancer established in our laboratory from 1973 to 2019,the clinical phenotypes and survival of 3050 patients with early esophageal invasive squamous cell cancer in a tertiary hospital were compared and analyzed.The diagnosis time of these patients was divided into four periods(1974-1986,1987-1997,1998-2008 and 2009-2019).The main factors influencing the prognosis of patients with early esophageal invasive squamous cell cancer were analyzed by life table method,Kaplan-Meier analysis and Cox regression analysis.Results Of the 3050 patients with esophageal early invasive squamous cell cancer,the detection rate of esophageal early invasive squamous cell cancer was significantly increased in four time periods(χ^2=1793.785,P<0.001),31 patients(0.52%)were from 1974-1986,165 patients(0.80%)were from 1987-1997,949 patients(3.39%)were from 1998-2008,1905 patients(7.98%)were from 2009-2019.Cox regression analysis showed that age was an independent prognostic factor for esophageal early invasive squamous cell cancer.Conclusion The detection rate of early esophageal invasive squamous cell cancer increases gradually from 1973 to 2019,age is an independent prognostic factor of early esophageal invasive squamous cell cancer.
作者
宋昕
赵学科
侯志超
王伟
李欣然
杨苗苗
徐瑞华
魏梦霞
韩文莉
雷玲玲
孟超龙
胡守佳
程锟
王盼盼
钟侃
胡景峰
李留玉
吉佳佳
杨媛啧
陈瑶
王立东
SONG Xin;ZHAO Xueke;HOU Zhichao;WANG Wei;LI Xinran;YANG Miaomiao;XU Ruihua;WEI Mengxia;HAN Wenli;LEI Lingling;MENG Chaolong;HU Shoujia;CHENG kun;WANG Panpan;ZHONG Kan;HU Jingfeng;LI Liuyu;JI Jiajia;YANG Yuanze;CHEN Yao;WANG Lidong(State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China;Department of Thoracic Surgery,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China;Department of Pathology and Pathophysiology,School of Basic Medicine Science,Zhengzhou University,Zhengzhou 450052,China)
出处
《肿瘤基础与临床》
2020年第5期369-372,共4页
journal of basic and clinical oncology
基金
国家自然科学基金资助项目(81472323)。
关键词
食管鳞癌
早期浸润癌
检出率
生存率
esophageal squamous cell cancer
early infiltrating cancer
detectable rate
survival rate
