摘要
肝性脑病(hepatic encephalopathy,HE)是急、慢性严重肝脏疾病较为常见的并发症之一,临床上以精神障碍的发展及认知能力的变化分为前驱期、昏迷前期、昏睡期、昏迷期。目前HE的发病机制尚不明确,处于中心地位的学说是“氨中毒学说”,治疗原则主要为减少肠道氨的产生以及加快氨的清除和代谢。近年来研究发现,肠道菌群失衡与HE的发生密切相关,本文重点探讨了肠道菌群与HE之间的联系和影响机制,以及基于菌群层面的HE的治疗方法。
Hepatic encephalopathy(HE)is one of the most common complications of acute and chronic severe liver diseases.Clinically,according to the development of mental disorders and the changes of cognitive ability,HE can be divided into prodromal stage,pre-comatose stage,comatose stage.At present,the pathogenesis of HE is still unclear.The central theory is“ammonia poisoning theory”.The treatment principle is to reduce the production of intestinal ammonia and accelerate the clearance and metabolism of ammonia.In recent years,studies have found that the imbalance of intestinal flora is closely related to the occurrence of HE.This paper focused on the relationship between intestinal flora and HE,the influence mechanism and the treatment methods based on the flora level.
作者
秦子文
刘晶涛
范晓红
孟彤
QIN Ziwen;LIU Jingtao;FAN Xiaohong;MENG Tong(The Second Clinical Medical College of Shanxi Medical University,Taiyuan 030001;Department of Gastroenterology,the Second Hospital of Shanxi Medical University,China)
出处
《胃肠病学和肝病学杂志》
CAS
2021年第1期34-37,共4页
Chinese Journal of Gastroenterology and Hepatology
关键词
肝性脑病
肠道菌群
微生态制剂
粪菌移植
Hepatic encephalopathy
Intestinal flora
Microecological agents
Fecal microbiota transplantation
