摘要
目的探讨血清肝细胞生长因子(HGF)、白细胞介素6(IL-6)水平对血液透析患者蛋白质-能量消耗的诊断价值。方法选取2014年1月至2017年12月在该院接受血液透析治疗的122例终末期肾病患者为研究对象,分为蛋白质-能量消耗组和非蛋白质-能量消耗组。观察患者临床指标及血清HGF、IL-6水平差异,分析血液透析患者发生蛋白质-能量消耗的危险因素,探讨血清HGF、IL-6对血液透析继发蛋白质-能量消耗的诊断价值。结果蛋白质-能量消耗组37例,非蛋白质-能量消耗组85例。蛋白质-能量消耗组患者年龄、透析月龄以及尿素氮、HGF、IL-6水平高于非蛋白质-能量消耗组,而体质量指数和血清转铁蛋白、清蛋白、前清蛋白、血红蛋白水平低于非蛋白质-能量消耗组,差异有统计学意义(P<0.05)。血液透析患者血清HGF、IL-6水平与营养指标血清转铁蛋白、清蛋白、前清蛋白、血红蛋白、总胆固醇、三酰甘油水平呈负相关(P<0.05)。多因素回归分析显示,年龄大、透析月龄长以及血清HGF、IL-6水平升高是血液透析患者发生蛋白质-能量消耗的独立危险因素(P<0.05)。HGF、IL-6联合检测诊断血液透析患者蛋白质-能量消耗的受试者工作特征曲线下面积为0.910,灵敏度为91.9%,特异度为80.0%。结论血清HGF、IL-6水平可作为筛查血液透析患者发生蛋白质-能量消耗的参考指标。
Objective To investigate the diagnostic value of serum levels of hepatocyte growth factor(HGF)and interleukin 6(IL-6)in patients with hemodialysis.Methods Totally 122 patients with end-stage renal disease in the hospital from January 2014 to December 2017 who received hemodialysis were selected and divided into protein energy consumption group and non protein energy consumption group.The clinical indicators and serum HGF,IL-6 levels were observed between the two groups,and the risk factors of protein energy consumption in hemodialysis patients were analyzed,and the diagnostic value of serum HGF and IL-6 for protein energy consumption secondary to hemodialysis was discussed.Results There were 37 cases in protein energy consumption group and 85 cases in non protein energy consumption group.The age,dialysis month age,blood urea nitrogen,HGF and IL-6 levels in protein energy consumption group were significantly higher than those in non protein energy consumption group,while body mass index,serum transferrin,albumin,prealbumin and hemoglobin levels in protein energy consumption group were lower than those in non protein energy consumption group(P<0.05).Serum HGF and IL-6 levels were negatively correlated with the levels of serum transferrin,albumin,prealbumin,hemoglobin,total cholesterol and triglycerides in hemodialysis patients(P<0.05).Multivariate regression analysis showed that older age,longer dialysis month age,high serum HGF and IL-6 levels were independent risk factors of protein energy consumption in hemodialysis patients(P<0.05).The area under the receiver operating characteristic curve of HGF and IL-6 combined detection in diagnosing protein energy consumption of hemodialysis patients was 0.910,the sensitivity and specificity were 91.9%and 80.0%,respectively.Conclusion Serum HGF and IL-6 levels can be used as a reference index for screening protein energy consumption in hemodialysis patients.
作者
李文静
史聪
宋培
王天智
刘翠红
LI Wenjing;SHI Cong;SONG Pei;WANG Tianzhi;LIU Cuihong(Department of Nephrology,the Third Hospital of Shijiazhuang City,Shijiazhuang,Hebei 050000,China)
出处
《国际检验医学杂志》
CAS
2021年第3期293-296,共4页
International Journal of Laboratory Medicine
基金
2018年河北省医学科学研究重点课题(20181059)。
