摘要
冰片在传统医学中常作为一味佐使药,在我国有着悠久的药用历史,现代医学也证实其对心脑血管等诸多疾病具有良好的治疗作用。近年来,国内外众多学者对冰片的药理作用及其机制进行了广泛研究,通过对相关研究资料进行整理和分析,发现冰片可促进药物通过血脑屏障、黏膜、胃肠道、皮肤等部位,可能发挥了引经作用。其内在分子机制包括抑制转运蛋白外泵功能、调节生物化学物质水平、改变皮肤角质层的结构变化以及疏松内皮细胞紧密连接结构等。为了进一步探讨冰片具有类似引经作用的科学内涵,以期为基于中药引经报使概念研究靶向给药系统的新思路提供理论参考,现就相关研究进行综述。
Borneol is often used as an adjuvant in traditional Chinese medicine and has a long history of medicinal use.Modern medicine also proved that borneol has a good therapeutic effect on cardiovascular and cerebrovascular diseases.Many scholars at home and abroad had carried out extensive research on the pharmacological effect and mechanism of borneol adjuvant theory in recent years.Based on the analysis of the research data in recent years,it can be found that borneol also plays a guiding action in the compatibility of medicines.Borneol can promote the passage of drugs through the blood-brain barrier,the mucosa,the gastrointestinal tract and the skin by summarizes the discussion.The synergistic molecular mechanisms of borneol include inhibiting the function of transporter excretion,regulating the level of biochemical substances,changing the structure of the stratum corneum,and loosening the tight connective structure of endothelial cells.In order to further exploring the scientific connotation of borneol in guiding action,with a view to providing a theoretical reference for a new idea of targeted drug delivery system based on the concept of guiding action in traditional Chinese medicine,a review of related research is now conducted.
作者
赵洋洋
郭玉洪
黄汕梅
银帮巧
唐耀平
ZHAO Yang-yang;GUO Yu-hong;HUANG Shan-mei;YIN Bang-qiao;TANG Yao-ping(Science Experiment Center of Guangxi University of Chinese Medicine,Nanning,530200,China;Ruikang Hospital Affiliated to Guangxi University of Chinese medicine,Nanning,530011,China)
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2021年第1期150-155,共6页
Journal of Nanjing University of Traditional Chinese Medicine
基金
国家自然科学基金(81774115,81460721)
广西中医药大学研究生教育创新计划项目(YCSZ2018011)。
关键词
冰片
引经
药理作用
分子机制
borneol
medicinal guide
pharmacological effects
molecular mechanisms
