摘要
目的系统评价四妙勇安汤治疗热毒炽盛证糖尿病足的临床效果。方法计算机检索中国知网、万方、维普、PubMed、Embase、Web of Science和The Cochrane Library数据库,检索时间均从建库至2020年2月15日。检索四妙勇安汤治疗糖尿病足热毒炽盛证的随机对照试验,在严格质量评价的基础上,采用RevMan 5.3软件进行meta分析。结果最终纳入19篇文献,1380例患者,治疗组694例,对照组686例。结果显示:治疗组总有效率高于对照组[RR=1.26,95%CI(1.20,1.33),P<0.00001],治疗组的踝肱指数(ABI)[MD=0.09,95%CI(0.07,0.12),P<0.00001]、足背动脉血流量[MD=7.46,95%CI(5.48,9.43),P<0.00001]、运动神经传导速度(MCV)[MD=7.44,95%CI(6.32,8.57),P<0.00001]、感觉神经传导速度(SCV)[MD=5.05,95%CI(4.05,6.05),P<0.00001]均显著高于对照组。两组血浆黏度[MD=-0.06,95%CI(-0.16,0.03),P=0.19]、空腹血糖(GLU)[MD=-0.20,95%CI(-0.66,-0.27),P=0.41]比较差异均无统计学意义。结论当前证据显示,四妙勇安汤可有效改善糖尿病足临床症状,增加ABI、足背动脉血流量、MCV、SCV,受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。
Objective To systematically evaluate the clinical efficacy of Simiao Yong’an Decoction in the treatment of diabetic foot with heat-toxin pattern.Methods CNKI,Wanfang Data,VIP,PubMed,Embase,Web of Science and The Cochrane Library databases were searched by computer.The retrieval time was from the establishment time of database to February 15,2020.The randomized controlled trials of Simiao Yong’an Decoction for the treatment of diabetic foot with blazing heat-toxin pattern were searched,on the basis of strict quality evaluation,the RevMan5.3 software was used for meta-analysis.Results Nineteen literatures were finally included,including 1380 patients.There were 694 cases in the treatment group and 686 cases in the control group.The results of meta-analysis showed that total effective rate(RR=1.26,95%CI[1.20,1.33],P<0.00001)in the treatment group were significantly higher than that in the control group.Ankle-brachial index(ABI)(MD=0.09,95%CI[0.07,0.12],P<0.00001),blood flow of dorsalis pedis artery(MD=7.46,95%CI[5.48,9.43],P<0.00001),motor nerve conduction velocity(MCV)(MD=7.44,95%CI[6.32,8.5],P<0.00001),sensory nerve conduction velocity(SCV)(MD=5.05,95%CI[4.05,6.05],P<0.00001)in the treatment group were significantly better than those in the control group.There were no significant differences in both whole plasma viscosity(MD=-0.06,95%CI[-0.16,0.03],P=0.19)and fasting blood glucose(GLU)(MD=-0.20,95%CI[-0.66,-0.27],P=0.41)between the two groups.Conclusion The current evidence shows that Simiao Yong’an Decoction can effectively improve the clinical symptoms of diabetic foot,increase ABI,blood flow of dorsalis pedis artery,MCV and SCV,decrease the level of GLU.Limited by the quantity and quality of the included studies,the above conclusions need to be verified by more high-quality studies.
作者
杜玉青
李友山
陈润铭
董学宇
安琪
刘亚莉
朱春艳
王璐
DU Yuqing;LI Youshan;CHEN Runming;DONG Xueyu;AN Qi;LIU Yali;ZHU Chunyan;WANG Lu(Department of Peripheral Vascular,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing100700,China;Department of Andrology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing100700,China)
出处
《中国医药导报》
CAS
2021年第2期118-123,131,共7页
China Medical Herald
基金
国家自然科学基金面上项目(81973849)。
关键词
四妙勇安汤
糖尿病足
热毒炽盛证
系统评价
META分析
Simiao Yong’an Decoction
Diabetic foot
Blazing heat-toxin pattern
Systematic review
Meta-analysis
