摘要
根据目前水溶性药物易泄漏、包封率低的不足,查阅近几年国内外相关文献,对其制备方法进行综述。总结水溶性药物脂质体制备方法的研究进展,为水溶性药物脂质体制备提供参考。脂质体包载水溶性药物在实验室研究中已取得不错的成果,但大工业生产较困难,还需深入研究。
To summarize the research progress of the preparation methods of water-soluble drug liposomes and provide reference for the preparation of water-soluble drug liposomes. According to the current shortcomings of easy leakage of water-soluble drugs and low encapsulation rate, the preparation methods of water-soluble drugs were reviewed by referring to relevant literatures in recent years. Liposome-encapsulated water-soluble drug has achieved good results in laboratory research, but it is difficult to produce in large industry, and further research is needed.
作者
王荷逸
黄思凡
王邦国
武鑫
陈建明
WANG He-yi;HUANG Si-fan;WANG Bang-guo;WU Xin;CHEN Jian-ming(School of Pharmacy,Inner Mongolia Medical University,Hohhot 010110,China;School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Shanghai Weier Laboratory,Shanghai 201712,China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2020年第23期1935-1938,共4页
Chinese Pharmaceutical Journal
基金
国家自然科学基金项目资助(81772749)
上海市青年科技启明星计划资助(18QB1400400)
上海市科技小巨人工程项目资助(1902HX76600)
上海青浦区产学研合作发展资金项目资助(青产学研2019-5)。
关键词
水溶性药物
脂质体
制备方法
water-soluble drug
liposome
preparation method
