摘要
目的:探讨高通量血液透析治疗慢性肾功能衰竭(CRF)患者的效果及对患者抗氧化功能的影响。方法:选取2013年1月-2018年1月在郑州市第一人民医院行常规门诊血液透析治疗的CRF患者140例,采用SPSS16.0软件生成随机数字分为高通量组、常规血透组各70例,患者均每周透析治疗3次,对比两组在研究开始时、透析治疗6个月后的各项实验室指标。结果:治疗前,高通量组和常规血透组患者的β2-MG、BUN、Scr、血磷、Kt/v、PTH、GSH-Px、TAC水平差异无统计学意义(P>0.05),治疗后,高通量组患者的β2-MG、BUN、血磷、PTH值均低于常规血透组(P<0.05),高通量组患者的GSH-Px、TAC水平及Kt/v值高于常规血透组(P<0.05)。结论:高通量血液透析治疗CRF患者能有效改善患者氧化应激水平并减轻对肾脏的损害。
Objective:To investigate the effect of high flux hemodialysis on patients with chronic renal failure(CRF)and the effect on antioxidant function. Methods:140 CRF patients were selected from January 2013 to January 2018 in the hospital for routine outpatient hemodialysis. SPSS16.0 software was used to divide patients into high-throughput group and conventional hematopoietic group by random number, with 70 cases in each group. Patients were dialyzed three times a week. Laboratory indicators of two groups at the beginning of the study, dialysis treatment after 6 months were compared. Results:Before treatment, there was no statistically significant difference in the levels of β2-MG, BUN, Scr, blood phosphorus, Kt/v, PTH, GSH-Px and TAC between the high throughput group and the conventional hemodialysis group(P>0.05). After treatment, the levels of β2-MG, BUN, serum phosphorus and PTH in the high throughput group were lower than those in the conventional hemodialysis group(P<0.05). The levels of GSH-Px, TAC and Kt/v in the patients in the high throughput group were higher than those in the conventional hemodialysis group(P<0.05). Conclusion:High flux hemodialysis treatment of CRF patients can effectively improve the oxidative stress levels and reduce renal damage.
作者
徐艳艳
XU Yan-yan(Zhengzhou First People's Hospital,Zhengzhou,Henan 450004,China)
出处
《黑龙江医学》
2021年第4期341-343,共3页
Heilongjiang Medical Journal
