摘要
胆管癌是恶性程度高、预后差的实体肿瘤,手术切除仍然是主要治疗手段。靶向以及免疫治疗是近年来逐渐受到重视的抗肿瘤手段,尤其是免疫治疗。胆管癌的肿瘤微环境复杂,除了间质和内皮细胞外,还包括大量免疫细胞,天然和适应性免疫系统也发挥作用。本文总结了胆管癌的免疫相关研究以及最新的免疫治疗临床试验。
Cholangiocarcinoma(CCA)is a group of solid tumors with high malignant degree and poor prognosis.Surgical resection has still been the main therapy options.Targeting therapy and immunotherapy are the main anti-tumor methods that have been paid more and more attention in recent years,especially immunotherapy.The tumor microenvironment of CCA is complex,which encompasses not only interstitial and endothelial cells,but also a large number of immune cells.In addition,the innate and adaptive immune systems also play a role.This article summarizes the immune-related studies of cholangiocarcinoma and the latest clinical trials of immunotherapy.
作者
施学兵
王敬晗
姜小清
Shi Xuebing;Wang Jinghan;Jiang Xiaoqing(The First Department of Biliary Surgery,Eastern Hepatobilliary Surgery Hosipital,Naval Medical University,Shanghai 200438,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2021年第1期77-80,共4页
Chinese Journal of Hepatobiliary Surgery
关键词
胆管肿瘤
肿瘤微环境
免疫治疗
Bile duct neoplasms
Tumor microenvironment
Immunotherapy
