摘要
脑卒中(stroke)是导致成年人残疾和死亡的第二大病因,缺血性脑卒中约占所有脑卒中病例的87%^([1]),成为了现代社会健康和生活质量的主要威胁。缺血性脑卒中(ischemic stroke)由于脑血流量严重减少,脑组织缺乏血液和氧气供应,最终导致神经元细胞死亡和脑梗死^([2])。
Cerebral ischemia-reperfusion injury(CIRI)refers to the phenomenon that the recovery of blood flow leads to the destruction of brain structure and the aggravation of metabolic damage of nerve function after cerebral ischemia.The pathophysiological mechanism of CIRI is complicated,which mainly involves biological processes such as apoptosis,inflammation,oxidative stress,autophagy and so on.Studies have shown that long noncoding RNAs(lncRNAs)and microRNAs(miRNAs)play an important role in the occurrence and development of many diseases.However,the mechanism of noncoding RNAs in CIRI has not been fully clarified.This article reviews the roles of lncRNAs and miRNAs in CIRI in order to provide a direction for further exploration in the future.
作者
张毅
冯康倪
陈鉴涛
梁孟亚
ZHANG Yi;FENG Kang-ni;CHEN Jian-tao;LIANG Meng-ya(The Second Department of Cardiac Surgery,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2021年第2期347-355,共9页
Chinese Journal of Pathophysiology
基金
广东省自然科学基金面上项目(No.2019A1515010218)。
