摘要
目的探讨三维动脉自旋标记(3D ASL)技术在评估不同程度颈动脉狭窄后大脑分水岭灌注状态方面的临床应用价值。方法收集2018年1月~2020年3月于脑病科初诊为缺血性脑血管病患者60例,经颈部彩色多普勒超声分别评估双侧颈动脉狭窄度。同时行3D ASL成像检查,使用Functool软件将原始数据自动生成脑血流量(CBF)伪彩图,分别于皮质分水岭前角及后角、放射冠及半卵圆中心选取兴趣区(ROI=200±20 mm^2),测量并分析不同程度颈动脉狭窄患者大脑分水岭区CBF值差异。结果共采集颈动脉120根,其中颈动脉无狭窄30根,轻度狭窄49根,中度狭窄26根,重度狭窄15根,颈动脉轻度狭窄患者皮质分水岭前、后角CBF值与颈动脉无狭窄患者差异无统计学意义(P>0.05),内分水岭区CBF值低于无狭窄患者,差异有统计学意义(P<0.05);颈动脉中度、重度狭窄患者皮质分水岭及内分水岭CBF值均明显低于无狭窄患者,差异有统计学意义(P<0.05)。结论3D ASL成像技术可敏感评估不同程度颈动脉狭窄患者大脑分水岭区脑灌注状态,对于患者治疗方案的选择以及预后评估具有重要应用价值。
Objective To investigate the clinical value of 3D ASL in assessing the perfusion status of cerebral watershed after different degrees of carotid stenosis.Methods Sixty patients with ischemic cerebrovascular disease who were initially diagnosed in the Department of encephalopathy from January 2018 to March 2020 were collected.The degree of bilateral carotid artery stenosis was evaluated by CDFI.Meanwhile,3D ASL imaging was performed,and the original data were automatically generated into a pseudo color map of cerebral blood flow(CBF)using functool software,and three-dimensional arterial spin labeling(3D ASL)imaging examination.The interest areas(ROI=200±20 mm^2)were selected from the front and back corners of the cortical watershed,the radial crown and the center of the semicircular circle.The CBF values of the cerebral watershed in patients with different degrees of carotid stenosis were measured and analyzed.Results There were 120 cases of carotid artery,30 cases of no stenosis,49 cases of mild stenosis,26 cases of moderate stenosis,15 cases of severe stenosis.There was no significant difference in CBF between the patients with mild stenosis and the patients without stenosis(P>0.05).The CBF value in the inner watershed was lower than that in the patients without stenosis(P<0.05),The CBF values of cortical watershed and internal watershed in patients with moderate and severe carotid stenosis were significantly lower than those in patients without stenosis(P<0.05).Conclusion 3D ASL imaging technology can sensitively evaluate the cerebral perfusion in the watershed area of patients with different degrees of carotid stenosis.It has important application value for the selection of treatment plan and prognosis evaluation of patients.
作者
周建国
符大勇
卢明聪
孟云
王欣欣
ZHOU Jianguo;FU Dayong;LU Mingcong;MENG Yun;WANG Xinxin(Department of Radiology,Nanjing University of Chinese Medicine Affiliated Lianyungang Hospital,Lianyungang 222004,China;Department of Ultrasonography,Nanjing University of Chinese Medicine Affiliated Lianyungang Hospital,Lianyungang 222004,China)
出处
《分子影像学杂志》
2021年第1期59-62,共4页
Journal of Molecular Imaging
基金
连云港市卫生健康委面上科研项目(201921)
南京医科大学康达学院2019年度科研发展基金课题(KD2019KYJJYB036)
江苏省卫生健康委2020年度医学科研项目(Z2020061)。
关键词
颈动脉
血流动力学
动脉自旋标记
脑血流量
carotid artery
hemodynamics
arterial spin labeling
cerebral blood flow
