摘要
哺乳动物的胃肠道寄居着复杂的微生物种群,这些微生物种群被称为肠道微生物群,其与宿主的健康和疾病状态息息相关。肠道菌群可以防止外源病原体在胃肠道中定植,这种现象被称为"定植抗力"。对肠道微生态的干扰,譬如抗生素的使用,可能会改变微生物的组成,影响宿主免疫功能,并导致定植抗性的丧失,从而使宿主易于被病原体定植。本文对肠道定植抗力的形成机制以及抗生素对定植抗力影响的研究进展进行综述,旨在为人们合理使用抗生素、研发抗生素替代疗法提供理论参考。
The gastrointestinal tract of mammals is home to a complex population of microorganisms,known as the gut microbiota,which is closely related to the state of health of the host.The intestinal flora can prevent the colonization of exogenous pathogens in the gastrointestinal tract,a phenomenon known as"colonial resistance".Disturbances to the intestinal microecology,such as the use of antibiotics,may change the composition of microorganisms,affect the host’s immune function,and cause the loss of colonization resistance,making the host vulnerable to colonization by pathogens.This article reviews the research on the mechanism of intestinal colonization resistance and the impact of antibiotics on colonization resistance,aiming to provide a theoretical reference for the rational use of antibiotics and researching alternative therapies for antibiotic treatment.
作者
方鼎丽
方芳
郭沁园
薛云新
王岱
Fang Ding-li;Fang Fang;Guo Qin-yuan;Xue Yun-xin;Wang Dai(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Xiamen University,Xiamen 361102)
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2021年第2期113-120,共8页
Chinese Journal of Antibiotics
基金
国家自然科学基金(No.81971905)
福建省海洋经济发展补助资金项目(No.FJHJF-L-2019-4)
福建省教育厅中青年教师教育科研项目(No.JT180009)
分子疫苗学与分子诊断学国家重点实验室开放研究项目(No.SKLVD2018KF005)。
关键词
抗生素
肠道菌群
定植抗力
Antibiotics
Intestinal flora
Colonization resistance
