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IRGM/Irgm1调节自噬和凋亡在炎症性疾病中的研究进展 被引量：2

Research Progress of Role of IRGM/Irgm1 in Regulating Autophagy and Apoptosis in Inflammatory Diseases
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摘要 免疫相关GTP酶(IRG)属于γ干扰素诱导性GTP酶家族成员,在γ干扰素介导的宿主抗感染和炎症免疫中起重要作用。正常情况下,IRGM(人类)/Irgm1(小鼠)表达水平较低,在机体受到感染或炎症刺激时,IRGM/Irgm1可被γ干扰素迅速诱导表达并迁移至细胞吞噬溶酶体膜上。目前人们对IRGM/Irgm1在疾病中的研究主要集中在炎性肠病、神经系统疾病以及肿瘤等疾病中。IRGM/Irgm1可能通过介导细胞自噬和凋亡调控疾病的进展,但具体机制目前尚不明确。IRGM/Irgm1作为细胞自噬与凋亡共同的调节蛋白,对多种疾病的发生、发展和转归起重要作用。 The immune related GTPase(IRG)is a member of interferon-γinduced GTPase family,which plays an important role in interferon-γmediated host anti-infection and inflammatory immunity.Under normal conditions,the expression of IRGM(human)/Irgm1(mouse)is low,but when the body is stimulated by infection or inflammation,it can be rapidly induced by interferon-γand transferred to the phagocytic lysosomal membrane.At present,the research of IRGM/Irgm1 in diseases mainly focuses on inflammatory bowel disease,nervous system disease and tumor.It is found that IRGM/Irgm1 may regulate the progress of diseases through mediating cell autophagy and apoptosis,but the specific mechanism is not clear yet.As a common regulatory protein of autophagy and apoptosis,IRGM/Irgm1 plays an important role in the occurrence,development and prognosis of many diseases.
作者 孙松 郝欣然 邹小乙 万鑫 张芳妮 孙博 于波 房绍红 SUN Song;HAO Xinran;ZOU Xiaoyi;WAN Xin;ZHANG Fangni;SUN Bo;YU Bo;FANG Shaohong(The Key Laboratory of Myocardial Ischemia,Chinese Ministry of Education,Harbin 150086,China;Department of Neurobiology,Harbin Medical University,Harbin 150086,China;Department of Cardiology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)
机构地区 心肌缺血教育部重点实验室 哈尔滨医科大学神经生物学教研室 哈尔滨医科大学附属第二医院心内科
出处 《医学综述》 CAS 2021年第5期882-888,共7页 Medical Recapitulate
基金 国家自然科学基金(81870353) 国家重点研发计划(2016YFC1301100)。
关键词 免疫相关GTP酶M 自噬 凋亡 Immune-related GTPase M Autophagy Apoptosis
分类号 R392.11 [医药卫生—免疫学]
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  • 1Adolph, T.E., Tomczak, M.F., Niederreiter, L., Ko, H.J., Bock, J., Martinez-Naves, E., Glickman, J.N., Tschurtschenthaler, M., Hartwig, J., Hosomi, S., Flak, M.B., Cusick, J.L., Kohno, K., lwawaki, T., Billmann-Born, S., Raine, T., Bharti, R., Lucius, R., Kweon, M.N., Marciniak, S.J., Choi, A., Hagen, S.J., Schreiber, S., Rosenstiel, P., Kaser, A., and Blumberg, R.S. (2013). Paneth cells as a site of origin for intestinal inflammation. Nature 503,272 276.
  • 2Anderson, C.A., Boucher, G., Lees, C.W., Franke, A., D'Amato, M., Taylor, K.D., Lee, J.C., Goyette, P., Imielinski, M., Latiano, A., Lagace, C., Scott, R., Amininejad, L., Bumpstead, S., Baidoo, L., Baldassano, R.N., Barclay, M., Bayless, T.M., Brand, S., Buning, C., Colombel, J.F., Denson, L.A., De Vos, M,, Dubinsky, M., Edwards, C., Ellinghaus, D., Fehrmann, R.S, Floyd, J.A., Florin, T., Franchimont, D., Franke, L., Georges, M., Glas, J., Glazer, N.L., Guthery, S.L., Haritunians, T., Hayward, N.K., Hugot, J.P., Jobin, G., Laukens, D., Lawrance, I., Lemann, M., Levine, A., Libioulle, C., Louis, E., McGovern, D.P., Milla, M., Montgomery, G.W., Morley, K.L, Mowat, C., Ng, A., Newman, W., Ophoft; R.A., Papi, L., Pahnieri, O., Peyrin-Biroulet, L., Panes, J., Phillips, A., Prescott, N.J., Proctor, D.D., Roberts, R., Russell, R., Rutgeerts, P., Sanderson, J., Sans, M., Schumm, P., Seibold, F., Sharma, Y., Simms, L.A., Seielstad, M., Steinhart, A.H., Targan, S.R., van den Berg, L.H., Vatn, M., Verspaget, H., Waiters, T., Wijmenga, C., Wilson, D.C., Westra, H.J., Xavier, R.J., Zhao, Z.Z., Ponsioen, C.Y., Andersen, V., Torkvist, L., Gazouli, M., Anagnou, N.P., Karlsen, T.H., Kupcinskas, L., Sventoraityte, J., Mansfield, J.C., Kugathasan, S., Silverberg, M.S., Halfvarson, J., Rotter, J.l., Mathew, C.G., Griffiths, A.M., Gearry, R., Ahmad, T., Brant, S.R., Chamaillard, M., Satsangi, J., Cho, J.H., Schreiber, S., Daly, M.J., Barrett, J.C., Parkes, M., Annese, V., Hakonarson, H., Radford-Smith, G., Duerr, R.H., Vermeire, S., Weersma, R.K., and Rioux, J.D. (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 43. 246-252.
  • 3Atarashi, K., Tanoue, T., Shima, T., lmaoka, A., Kuwahara, T., Momose,Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., Taniguchi, T., Takeda, K., Hori, S., Ivanov, II, Umesaki, Y., Itoh, K., and Honda, K. (2011). Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331,337-341.
  • 4Ayabe, T., Satchell, D.P., Wilson, C.L., Parks, W.C., Selsted, M.E., and Ouellette, A.J. (2000). Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 1, 113-118.
  • 5Barrett, J.C., Hansoul, S., Nicolae, D.L., Cho, J.H., Duerr, R.H., Rioux, J.D., Brant, S.R., Silverberg, M.S., Taylor, K.D., Barmada, M.M., Bitton, A., Dassopoulos, T., Datta, L.W., Green, T., Griffiths, A.M., Kistner, E.O., Murtha, M.T., Regueiro, M.D., Rotter, J.1., Schumm, L.P., Steinhart, A.H., Targan, S.R., Xavier, R.J., Libioulle, C., Sandor, C., Lathrop, M., Belaiche, J., Dewit, O., Gut, I., Heath, S., Laukens, D., Mni, M., Rutgeerts, P., Van Gossum, A., Zelenika, D., Franchimont, D., Hugot, J.P., de Vos, M., Vermeire, S., Louis, E., Cardon, L.R., Anderson, C.A., Drummond, H., Nimmo, E., Ahmad, T., Prescott, N.J., Onnie, C.M., Fisher, S.A., Marchini, l., Ghori, J., Bumpstead, S., Gwilliam, R., Tremelling, M., Deloukas, P., Mansfield, J., Jewell, D., Satsangi, J., Mathew, C.G., Parkes, M., Georges, M., and Daly, M.J. (2008). Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40, 955-962.
  • 6Bevins, C.L., and Salzman, N.H. (2011). Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 9, 356-368.
  • 7Billmann-Born, S., Till, A., Arlt, A., Lipinski, S., Sina, C., Latiano, A., Annese, V., Hasler, R., Kerick, M., Manke, T., Seegert, D., Hanidu, A., Schafer, H., van Heel, D., Li, J., Schreiber, S., and Rosenstiel, P. (2011). Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC. J Immunol 186, 40274038.
  • 8Cadwell, K., Liu, J.Y., Brown, S.L., Miyoshi, H., Lob, J., Lennerz, J.K., Kishi, C., Kc, W., Carrero, J.A., Hunt, S., Stone, C.D., Brunt, E.M., Xavier, R.J., Sleckman, B.P., Li, E., Mizushima, N., Stappenbeck, T.S., and Virgin, H.W.4th. (2008). A key role for autophagy and the autophagy gene Atgl611 in mouse and human intestinal Paneth cells. Nature 456, 259-263.
  • 9Cadwell, K., Patel, K.K., Maloney, N.S., Liu, T.C., Ng, A.C., Storer, C.E., Head, R.D., Xavier, R., Stappenbeck, T.S., and Virgin, H.W. (2(110). Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atgl6L1 phenotypes in intestine. Cell 141, 1135-1145.
  • 10Cash, H.L., Whitham, C.V., Behrendt, C.L., and Hooper, L.V. (2006). Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313, 1126-1130.

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医学综述
2021年 第5期

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