摘要
CD4^(+)T细胞经T细胞受体介导活化后主要分为辅助性T细胞(Th细胞)1、Th2、Th17和调节性T细胞(Treg细胞)4个细胞亚群,各亚群间互相调节,参与不同类型的免疫应答,共同发挥免疫学功能,其中细胞因子和转录因子对CD4^(+)T细胞的分化、增殖和效应细胞因子产物起重要的调节作用。经典的免疫学说认为,Th1/Th2细胞免疫模式失衡是诱发自身免疫性疾病(AID)的主要机制。近年来,随着Th17和Treg细胞亚群的发现和研究的不断深入,不仅弥补了单纯由Th1/Th2细胞介导自身免疫效应机制的缺陷,丰富了传统Th1/Th2细胞免疫理论的内涵,拓展了对AID发生机制的认识,也有助于了解神经系统AID的发病机制,从而为寻找有效的治疗靶点及选择安全可靠的新药提供依据。
After T cell receptor-mediated activation,CD4^(+)T cells are mainly divided into four subsets,namely helper T cell(Th)1,Th2,Th17 and regulatory T cell(Treg),which regulate each other,participate in different types of immune responses,and exert immunological functions together.Among them,cytokines and transcription factors play an important role in regulating the differentiation and proliferation of CD4^(+)T cells and the production of effector cytokines.Traditionally,the Th1/Th2 immune model is considered to be a classic immune theory,and the imbalance between them is the main mechanism for inducing autoimmune diseases(AID).In recent years,with the continuous deepening of the discovery and research of Th17 and Treg cell subsets,it not only makes up for the defect of the mechanism of autoimmune effect mediated by Th1/Th2 cells,but also enriches the connotation of traditional Th1/Th2 cellular immune theory,expands the understanding of the pathogenesis of AID,and helps to understand the pathogenesis of AID of nervous system,therefore helps to find out the effective therapeutic targets and select the safe and reliable new drugs.
作者
李红岩
侯振江
刘建凤
陈云霞
LI Hongyan;HOU Zhenjiang;LIU Jianfeng;CHEN Yunxia(Department of Medical Technology,Cangzhou Medical College,Cangzhou 061001,China;Institute of Thyroid Diseases Affiliated to Cangzhou Medical College/Cangzhou Thyroid Disease Engineering Technology Research Center,Cangzhou 061001,China;Department of Endocrinology,Cangzhou People′s Hospital,Cangzhou 061001,China)
出处
《医学综述》
CAS
2021年第5期889-895,900,共8页
Medical Recapitulate
基金
沧州市重点研发计划指导项目(183302011)
沧州医学高等专科学校校级科研课题(18Z015)。
