摘要
目的探讨血清血管性血友病因子(vWF)、白细胞介素-6(IL-6)、降钙素原(PCT)及凝血功能指标在急性白血病合并感染患者诊断中的应用价值。方法回顾性分析吴川市人民医院2018年1月至2020年2月收治的150例急性白血病患者的临床资料,根据是否感染分为脓毒症组30例、普通感染组59例、未感染组61例,检测三组患者的v WF、IL-6、PCT及凝血功能指标[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D二聚体(D-D)],采用Pearson相关分析血清vWF、IL-6、PCT及凝血功能间的相关性。结果脓毒症组患者的血清vWF、IL-6、PCT水平分别为(325.53±74.91)%、(124.85±36.05)ng/L、(5.97±0.88)ng/mL,明显高于普通感染组的(220.10±39.4)%、(50.32±7.14)ng/L、(2.34±0.41)ng/mL和未感染组的(117.42±26.28)%、(9.06±1.38)ng/L、(0.75±0.19)ng/mL,且普通感染组患者的血清vWF、IL-6、PCT又明显高于未感染组,差异均有统计学意义(P<0.05);脓毒症组患者的APTT、PT、FIB、D-D水平分别为(41.04±2.78)s、(15.95±1.45)s、(6.12±0.68)g/L、(5.62±0.77)mg/L,明显长于或高于普通感染组的(35.63±2.04)s、(14.10±1.09)s、(4.20±0.45)g/L、(2.15±0.31)mg/L和未感染组的(27.17±2.31)s、(12.97±0.65)s、(3.12±0.61)g/L、(0.42±0.05)mg/L,且普通感染组患者的血清APTT、PT、FIB、D-D又明显长于或高于未感染组,差异均有统计学意义(P<0.05);经Pearson相关分析结果显示,血清vWF、IL-6、PCT及凝血功能之间均呈明显正相关(P<0.05)。结论随着急性白血病患者感染程度的加重,血清vWF、IL-6、PCT的表达随之升高,凝血功能也被逐渐激活,血管内皮损伤、炎症反应、凝血功能紊乱三者共同促进了疾病进展,对其检测有助于判断感染严重程度。
Objective To study the application value of serum Von Willebrand factor(vWF),interleukin-6(IL-6),procalcitonin(PCT),and coagulation function indexes in the diagnosis of patients with acute leukemia complicated with infection.Methods The clinical data of 150 patients with acute leukemia in Wuchuan People’s Hospital from January 2018 to February 2020 were retrospectively analyzed.According to whether they were infected,the patients were divided into 30 patients in the sepsis group,59 patients in the normal infection group and 61 patients in the uninfected group.The expression of vWF,IL-6,PCT and coagulation function index(activated partial thromboplastin time[APTT],prothrombin time[PT],fibrinogen[FIB]and D two dimer[D-D])were detected in three groups,and Pearson correlation analysis was used to analyze the correlation of serum vWF,IL-6,PCT and coagulation function.Results The serum vWF,IL-6,and PCT in sepsis group were(325.53±74.91)%,(124.85±36.05)ng/L,(5.97±0.88)ng/mL,respectively,which were significantly higher than corresponding(220.10±39.4)%,(50.32±7.14)ng/L,(2.34±0.41)ng/m L in the normal infection group and corresponding(117.42±26.28)%,(9.06±1.38)ng/L,(0.75±0.19)ng/m L in the uninfected group,and the serum vWF,IL-6 and PCT in normal infection group patients were significantly higher than those in uninfected group(all P<0.05);the APTT,PT,FIB,and D-D in the sepsis group were(41.04±2.78)s,(15.95±1.45)s,(6.12±0.68)g/L,(5.62±0.77)mg/L,respectively,which were significantly longer/higher than corresponding(35.63±2.04)s,(14.10±1.09)s,(4.20±0.45)g/L,(2.15±0.31)mg/L in the normal infection group and corresponding(27.17±2.31)s,(12.97±0.65)s,(3.12±0.61)g/L,(0.42±0.05)mg/L in the uninfected group,and those in the normal infection group were significantly longer/higher than those in uninfected group(all P<0.05);the results of Pearson correlation analysis showed that there was significant positive correlation between VWF,IL-6,PCT and coagulation(P<0.05).Conclusion With the aggravation of infection in acute leukemia patients,the expression of serum vWF,IL-6,and PCT is increased,and the coagulation function is activated gradually.The vascular endothelial injury,inflammatory reaction and coagulation dysfunction promote the progress of the disease,and the detection is helpful to judge the severity of infection.
作者
李海波
陈静娴
冼朝丽
LI Hai-bo;CHEN Jing-xian;XIAN Chao-li(Department-of Clinical Laboratory,Wuchuan People's Hospital,Wuchuan 524500,Guangdong,CHINA)
出处
《海南医学》
CAS
2021年第5期580-583,共4页
Hainan Medical Journal
关键词
急性白血病
感染
血管性血友病因子
白细胞介素-6
降钙素原
凝血功能
Acute leukemia
Infection
Von Willebrand factor(vWF)
Interleukin-6(IL-6)
Procalcitonin(PCT)
Coagulation function
