摘要
目的:探讨白百抗痨颗粒对肺结核伴咯血患者痰菌转阴时间及病灶吸收的影响。方法:选择2019年2月—2020年2月本院收治的肺结核伴咯血患者90例,依据掷硬币分组法将其分成对照组(n=43)和观察组(n=47)。对照组采用常规西药治疗,给予利福平口服,0.45 g/次,1次/d;异烟肼口服,0.3 g/次,1次/d;吡嗪酰胺口服,0.25 g/次,1次/d;乙胺丁醇口服,0.75 g/次,1次/d;若患者伴小量咳血,则静脉注射止血芳酸0.1 g/次,1次/d,止血敏30 ml/次,2~3次/d,连续用药3 d;若患者伴中量咳血,则予以6 U垂体后叶素静脉滴注,止血后停药;若患者伴大量咳血,则予以输液泵持续静脉泵入垂体后叶素,止血后停药。观察组在对照组基础上加用白百抗痨颗粒温水冲服,15 g/次,2~3次/d,大量咳血患者需解除禁食后服用。治疗3个月后,比较两组病灶吸收率、临床症状改善时间、不良反应发生率。结果:观察组病灶吸收率为95.74%,高于对照组的74.42%,差异有统计学意义(P<0.05);治疗后,与对照组比较,观察组咳血停止及结核中毒症状好转时间均较短,差异有统计学意义(P<0.05);观察组不良反应发生率为8.51%,对照组不良反应发生率为11.63%,组间比较差异无统计学意义(P>0.05)。结论:肺结核伴咳血患者应用白百抗痨颗粒治疗可有效促进其病灶吸收,缩短其临床症状改善时间,且不会增加不良反应,安全性较高。
Objective:To investigate the effect of Baibaibaikanglao Granule on the sputum negative time and absorption of lesions in patients with tuberculosis and hemoptysis.Methods:A total of 90 patients with pulmonary tuberculosis with hemoptysis admitted to our hospital from February 2019 to February 2020 were selected and divided into control group(n=43)and observation group(n=47)according to the coin tossing method.The control group was treated with conventional therapy:rifampicin(0.45 g/time,once a day),isoniazid(0.3 g/time,once a day),pyrazinamide(0.25 g/time,once a day),and ethylamine butanol(0.75 g/time,once a day).If the patient was accompanied by a small amount of hemoptysis,p-aminomethylbenzoic acid(0.1 g/time,once a day)and etamsylate(30 mL/time,twice or three times a day)was given by intravenous injection for three consecutive days.If the patient had moderate hemoptysis,6 U pituitrin was given by intravenous drip,and the drug was stopped after hemostasis.If the patient was accompanied by massive hemoptysis,the infusion pump was used to pump pituitrin into the vein continuously,and the drug was stopped after hemostasis.On the basis of the control group,the observation group was additionally given Baibaibaikanglao Granule(15 g/time,twice or three times a day)with warm water.Patients with massive hemoptysis should take it after lifting their fasting.After three months of treatment,the absorption rate of sputum lesions,the time of improvement of clinical symptoms,and the incidence of adverse reactions were compared between the two groups.Results:The absorption rate of the observation group was 95.74%,which was statistically higher than that of the control group(74.42%,P<0.05).After treatment,compared with the control group,the time of stopping hemoptysis and improving symptoms of tuberculosis poisoning in the observation group was shorter,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 8.51%,and that in the control group was 11.63%.There was no significant difference between the two groups(P>0.05).Conclusion:The application of Baibaibaikanglao Granule in the treatment of pulmonary tuberculosis with hemoptysis can effectively promote the absorption of the lesions,shorten the improvement time of clinical symptoms,and would not increase adverse reactions.Conclusion:The treatment of pulmonary tuberculosis with hemoptysis can effectively promote the absorption of lesions,shorten the time of improvement of clinical symptoms,and not increase adverse reactions.
作者
张欣欣
Zhang Xinxin(Zhengzhou Sixth People’s Hospital,Henan 450000)
出处
《天津药学》
2021年第1期58-60,共3页
Tianjin Pharmacy
关键词
肺结核伴咳血
白百抗痨颗粒
病灶吸收率
临床症状改善时间
不良反应发生率
pulmonary tuberculosis with hemoptysis
Baibaibaikanglao Granules
focal absorption rate
improvement time of clinical symptoms
incidence of adverse reactions
