摘要
目的观察莫西沙星治疗慢性阻塞性肺疾病急性加重期(AECOPD)高龄患者的临床效果。方法将130例高龄AECOPD患者随机分为研究组和对照组,每组65例。对照组采用基础治疗联合头孢哌酮/舒巴坦的方案,研究组采用基础治疗联合莫西沙星的方案。比较2组治疗前后第1秒用力呼气容积占预计值百分比(FEV 1%)、最大通气量(MVV)、第1秒用力呼气容积占用力肺活量比率(FEV_(1)/FVC)、血清谷胱甘肽过氧化物酶(GPx)、超氧化物歧化酶(SOD)、一氧化氮(NO)、丙二醛(MDA)、内皮素(ET-1)、可溶性细胞间黏附分子-1(sICAM-1)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)、C反应蛋白(CRP)水平。结果治疗后,研究组FEV 1%、MVV、FEV 1/FVC、SOD、GPx、NO水平高于对照组,MDA、ET-1、sICAM-1、IL-8、TNF-α、PCT、CRP水平低于对照组,差异均有统计学意义(P<0.05)。结论莫西沙星在高龄AECOPD患者中的抗感染效果更好,可减轻患者的炎症反应、血管内皮损伤,增强抗氧化功能。
Objective To observe the clinical efficacy of moxifloxacin in the treatment of senile patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Totally 130 senile patients with AECOPD were randomly divided into study group and control group,with 65 cases in each group.The control group was treated with cefoperazone/sulbactam and routine therapy,while the study group was treated with moxifloxacin and routine therapy.Indexes such as percentage of forced expiratory volume in the first second in predict value(FEV_(1)%),maximum ventilation(MVV),ratio of forced expiratory volume in the first second to forced vital capacity(FEV_(1)/FVC),serum glutathione peroxidase(GPx),superoxide dismutase(SOD),nitric oxide(NO),malondialdehyde(MDA),endothelin(ET-1),soluble intercellular adhesion molecule-1(sICAM-1),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),procalcitonin(PCT)and C-reactive protein(CRP)before and after treatment were compared between two groups.Results After treatment,the levels of FEV 1%,MVV,FEV 1/FVC,SOD,GPx and NO in the study group were significantly higher than those in the control group,while the levels of MDA,ET-1,sICAM-1,IL-8,TNF-α,PCT and CRP were significantly lower than those in the control group(P<0.05).Conclusion Moxifloxacin has a better anti-infection efficacy in treating senile patients with AECOPD,which can reduce the inflammatory reaction and vascular endothelial injury,and enhance anti-oxidant function.
作者
沈波
张浩
毛爽
王立斌
李雪薇
SHEN Bo;ZHANG Hao;MAO Shuang;WANG Libin;LI Xuewei(The Third Department of Internal Medicine,The People′s Hospital of Shenyang Economic and Technological Development Zone,Shenyang,Liaoning,110000;Department of Respiratory and Critical Care Medicine,Air Force Hospital of Northern Theater,Shenyang,Liaoning,110000;Department of Respiratory Medicine,Huanggu Branch of Northeast International Hospital,Shenyang,Liaoning,110000;Department of Respiratory Medicine,Liaoning Provincial People′s Hospital,Shenyang,Liaoning,110000)
出处
《实用临床医药杂志》
CAS
2021年第1期54-57,共4页
Journal of Clinical Medicine in Practice
基金
辽宁省科学技术计划项目(2019225034)。
关键词
莫西沙星
慢性阻塞性肺疾病急性加重期
超氧化物歧化酶
丙二醛
可溶性细胞间黏附分子-1
内皮素
moxifloxacin
acute exacerbation of chronic obstructive pulmonary disease
superoxide dismutase
malondialdehyde
soluble intercellular adhesion molecule-1
endothelin
