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双歧杆菌四联活菌治疗小儿急性淋巴细胞白血病的研究 被引量:1

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摘要 目的:探究双歧杆菌四联活菌治疗小儿急性淋巴细胞白血病效果。方法:选取2018年5月~2019年6月收治的小儿急性淋巴细胞白血病患儿84例为研究对象,随机分为对照组和观察组,各42例。对照组行常规化疗并适当调整化疗剂量,观察组在对照组治疗基础上口服思联康。比较治疗4周后两组化疗效果、严重毒副反应、胃肠功能(血浆胃动素、血清胃泌素)、免疫功能(CD3^(+)、CD4^(+)、CD8^(+)、自然杀伤细胞)。结果:治疗4周后,两组客观缓解率比较,差异无统计学意义(P>0.05);两组CD3^(+)、CD4^(+)、自然杀伤细胞、血清胃泌素、血浆胃动素水平均较治疗前升高,且观察组高于对照组(P<0.05);两组CD8^(+)水平较治疗前降低,且观察组低于对照组(P<0.05);观察组严重毒副反应发生率低于对照组(P<0.05)。结论:联用双歧杆菌四联活菌能在确保小儿急性淋巴细胞白血病合并胃肠功能紊乱患儿化疗效果的同时,有效改善胃肠功能,增强细胞免疫功能并减少严重毒副反应。
出处 《实用中西医结合临床》 2021年第3期39-40,77,共3页 Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
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  • 1褚旭芳.思连康联合思密达治疗小儿腹泻的临床疗效分析[J].医学信息(医学与计算机应用),2014,0(2):396-397. 被引量:4
  • 2Gao C, Zhao XX, Li WJ, et al. Clinical features, early treatment responses, and outcomes of pediatric acute lymphoblastic leukemia in China with or without specific fusion transcripts : a single institutional study of 1,004 patients. Am J I-tematol, 2012 , 87 ( 11 ) : 1022 - 1027.
  • 3Rubnitz JE, Wichlan D, Devidas M, et al. Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia : a Children's Oncology Group study. J Clin Oncol,2008 ,26 (13): 2186 -2191.
  • 4Forestier E, Heyman M, Andersen MK, et al. Outcome of ETV6/ RUNX1-positive childhood acute lymphoblastic leukaemia in the NO- PHO-ALL-1992 protocol: frequent late relapses but good overall sur- vival. Br J Haematol,2008 , 140 (6) :665 - 672.
  • 5Bruggemann M, Schrauder A, Raft T, et al. Standardized MRD quantification in European ALL trials : proceedings of the Second In- ternational Symposium on MRD assessment in Kiel, Germany, 18 - 20 September 2008. Leukemia,2010 ,24 (3) :521 - 535.
  • 6van der Velden VH, Cazzaniga G, Schrauder A, et al. Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data. Leukemia, 2007 ,21 (4) :604 -611.
  • 7van der Velden VH, Panzer-Grumayer ER, Cazzaniga G, et al. Op- timization of PCR-based minimal residual disease diagnostics for childhood acute lymphoblastic leukemia in a multi-center setting. Leukemia,2007 , 21 ( 4 ) :706 - 713.
  • 8Nguyen K, Devidas M, Cheng SC, et al. Factors influencing surviv- al after relapse from acute lymphoblastic leukemia: a Children's On- cology Group study. Leukemia,2008 ,22(12) :2142 - 2150.
  • 9Teachey DT, Hunger SP. Predicting relapse risk in childhood acute lymphoblastic leukaemia. Br J Haematol,2013 ,162(5) :606 -620.
  • 10Eoh ML, Goldwasser MA, Silverman LB, et al. Prospective analysis of TEL/AMLl-positive patients treated on Dana-Farber Cancer Insti- tute Consortium Protocol 95-01. Blood, 2006, 107 ( 11 ) :4508 - 4513.

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