摘要
脾主运化,为气血生化之源。脾失健运,痰瘀互结,瘀滞日久,脉道不利,最终引发动脉粥样硬化(atherosclerosis,AS)发生。中医认为维持肠道菌群稳态是脾主运化的重要生理功能。肠道菌群作为人体内具有生物屏障、营养、免疫等多种生物学作用的重要"器官",其稳态失衡,将影响人体正常健康状态,其机制可能为肠道菌群失调诱导脂多糖(lipopolysaccharide,LPS)释放驱动巨噬细胞糖代谢重编程引发炎症反应继而导致AS发生。
Spleen governing transportation and transformation is the source of Qi and blood.Dysfunction of spleen in transportation,blood stasis-phlegm,long-term stagnation and vessels obstruction eventually lead to atherosclerosis(AS).Traditional Chinese medicine thinks that maintaining gut microbiota is an important physiological function of spleen governing transportation and transformation.Gut microbiota is an important"organ"with biological barriers,nutrition,immunity and other biological functions in the human body,and its steady-state imbalance will affect the normal health of the human body,and its mechanism is that lipopolysaccharide(LPS)which is induced by gut microbiota imbalance drives macrophage glycobolism reprogramming,and triggers an inflammatory response which in turn leads to AS.
作者
贾连群
隋国媛
宋囡
吕美君
杜莹
陈丽娟
战凯璇
曹慧敏
曹媛
杨关林
JIA Lianqun;SUI Guoyuan;SONG Nan;LYU Meijun;DU Ying;CHEN Lijuan;ZHAN Kaixuan;CAO Huimin;CAO Yuan;YANG Guanlin(Key Laboratory of Ministry of Education for Traditional Chinese Medicine Viscera-State Theory and Applications,Ministry of Education of China,Shenyang 110847,Liaoning,China;Chinese Medicine Innovation Engineering Technology Center,Shenyang 110847,Liaoning,China;National and Local Joint Engineering Laboratory for Integrated Chinese and Western Medicine Prevention and Treatment Technology on Angina Pectoris Complicated with Atherosclerotic Thrombotic Cerebral Infarction,Shenyang 110847,Liaoning,China)
出处
《中华中医药学刊》
CAS
北大核心
2021年第2期1-3,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金(81774022,81803860,81974548)
沈阳市高层次人才创新计划(RC170248)。
关键词
脾失健运
糖代谢重编程
肠道菌群
巨噬细胞
dysfunction of spleen in transportation
glycobolism reprogramming
gut microbiota
macrophage
