摘要
体外实验发现槐定碱能浓度相关地抑制大肠癌LS174t细胞、SW620细胞、SW480细胞、HCT-116细胞,胃癌BGC823细胞、MGC-803细胞、SGC7901细胞、MKN45细胞、MKN28细胞,胰腺癌capan-1细胞,肝癌97H细胞、Bel细胞、HepG2细胞,食管癌EC109细胞,食管胃交界腺癌OE-19细胞、SK-GT2细胞,白血病K562细胞、HL60细胞,淋巴瘤U937细胞,骨髓瘤NS-1细胞,乳腺癌MCF-7细胞,卵巢癌PM-2细胞、SKVO3细胞,宫颈癌HeLa细胞,肺癌A549细胞、NCI细胞,DMS153细胞,黑素瘤A375细胞,舌鳞癌TCA8113细胞,神经胶质瘤U87细胞、U87MG细胞,前列腺癌PC3细胞增殖。整体实验发现槐定碱抑制SW480细胞、HCT-116细胞,白血病L1210细胞,肺癌Lewis细胞,肉瘤S180细胞、S37细胞、W256细胞、EAC细胞移植瘤在小鼠或大鼠体内生长。临床上槐定碱已被试用于治疗恶性滋养细胞肿瘤、消化道肿瘤、恶性淋巴瘤,有开发成抗肿瘤新药的潜力。
Sophoridine inhibits proliferation in association with dosage on large intestine carcinoma LS174 t cells,SW620 cells,SW480 cells,HCT-116 cells,and gastric carcinoma BGC823 cells,MGC-803 cells,SGC7901 cells,MKN45 cells,MKN28 cells,and pancreatic cancer capan-1 cells,and hepatoma 97 H cells,Bel cells,HepG2 cells,and carcinoma of esophagus EC109 cells,and esophagogastric junctional adenocarcinoma OE-19 cells,SK-GT2 cells,and leukemia K562 cells,HL-60 cells,and lymphoma U937 cells,and myeloma NS-1 cells,and mammary cancer MCF-7 cells,and ovarian carcinoma PM-2 cells,SKOV3 cells,and cervical carcinoma HeLa cells,and lung cancer A549 cells,NCI cells,DMS153 cells,and melanoma A375 cells,squamous carcinoma of tongue TCA8113 cells,neuroglioma U87 cells,U87 MG cells,and prostatic carcinoma PC3 cells,in vitro.Sophoridine has the effect in inhibiting transplant growth of SW480 cells,HCT-116 cells,and leukemia L1210 cells,and lung cancer Lewis cells,sarcoma S180 cells,S37 cells,W256 cells,EAC cells in mice or rats.In clinic,sophoridine has been tried to treat for malignant choriocarcinoma,digestive system tumors,and malignant lymphoma,so it has the potential to develop new anti-tumor drugs.
作者
张明发
沈雅琴
ZHANG Mingfa;SHEN Yaqin(Shanghai Meiyou Pharmaceutical Co.Ltd.,Shanghai 201204,China)
出处
《药物评价研究》
CAS
2021年第2期452-460,共9页
Drug Evaluation Research
关键词
槐定碱
消化系统肿瘤
妇科肿瘤
肉瘤
白血病
肺癌
神经胶质瘤
sophoridine
digeatric system tumors
gynecologic tumors
sarcoma
leukemia
lung cancer
neuroglioma
