摘要
目的观察急性脑梗死患者血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)表达情况,分析PLR、NLR与患者动脉粥样硬化斑块的相关性。方法前瞻性选择2017年1月至2019年6月期间在池州市人民医院接受治疗并符合入选标准的急性脑梗死患者80例作为研究对象,另选同期在池州市人民医院接受常规健康体检并证实为健康者人群36例作为健康对照组。全部入选者均接受颈动脉彩色多普勒超声检查、血小板计数、中性粒细胞、淋巴细胞等实验室指标检查,根据检查结果计算NLR、PLR比值;按照颈部彩色多普勒超声检查的颈动脉内-中膜厚度将急性脑梗死80例患者分为硬化斑块组与非硬化斑块组,比较3组颈动脉内-中膜厚度、PLR、NLR,分析颈动脉内-中膜厚度与NLR、PLR相关性;制作受试者工作特征(ROC)曲线检验NLR、PLR用于预测急性脑梗死患者颈动脉粥样硬化斑块形成的效能。结果 80例急性脑梗死患者,经查有41例患者有颈动脉粥样硬化斑块形成,形成率为51.25%。3组中,斑块硬化组颈动脉内-中膜厚度、NLR、PLR值最高[(1.44±0.25) mm、3.20±0.84、143.47±58.38],其次为非斑块硬化组[(1.12±0.18) mm、2.41±0.54、119.00±48.91],健康对照组[(0.77±0.09) mm、1.81±0.46、68.99±21.85]最低,组间比较差异有统计学意义(P <0.05)。经双变量直线相关性检验结果显示,急性脑梗死患者颈动脉内-中膜厚度与NLR、PLR值均呈正相关(r=0.571、0.475,P <0.05);经ROC曲线分析结果显示,NLR、PLR用于急性脑梗死动脉粥样硬化斑块形成的预测的ROC曲线下面积分别为0.845、0.742。结论急性脑梗死患者NLR、PLR高表达可能与颈动脉粥样硬化斑块形成有关,考虑NLR、PLR的升高对预测急性脑梗死患者颈动脉粥样硬化斑块形成有一定价值。
Objective To observe the expression of platelet-to-lymphocyte ratio(PLR)and neutrophil-to-lymphocyte ratio(NLR)of patients with acute cerebral infarction,and to analyze the correlation of PLR and NLR with carotid atherosclerostic plaque.Methods Eighty patients with acute cerebral infarction who treated in the Chizhou People's Hospital from January 2017 to June 2019 were enrolled prospectively in the study.36 healthy people with routine physical examination in the Chizhou People's Hospital were selected as healthy control group.All selected cases underwent carotid artery color Doppler ultrasound examination,platelet count,neutrophil and lymphocyte examination,and the NLR and PLR were calculated according to the test results;80 patients with acute myocardial infarction were divided into atherosclerotic plaque group and non-atherosclerotic plaque group according to carotid intima-media thickness detected by carotid color Doppler ultrasound.The carotid intima-media thickness,PLR,NLR of three groups were compared.The correlation of carotid intima-media thickness with NLR and PLR was analyzed.The receiver operating characteristics(ROC)curve was used to test the efficiency of NLR and PLR for predicting the carotid atherosclerotic plaque in patients with acute cerebral infarction.Results Of the 80 patients with acute cerebral infarction,41 patients had carotid atherosclerotic plaque,and the formation rate was 51.25%.Among the three groups,the carotid intima-media thickness,NLR and PLR in atherosclerotic plaque group[(1.44±0.25)mm,3.20±0.84,143.47±58.38]were the highest,followed by non-atherosclerotic plaque group[(1.12±0.18)mm,2.41±0.54,119.00±48.91],and healthy control group[(0.77±0.09)mm,1.81±0.46,68.99±21.85]were the lowest(P<0.05).The results of bivariate linear correlation test showed that carotid intima-media thickness was positively correlated with NLR and PLR in patients with acute cerebral infarction(r=0.571,0.475,P<0.05).The ROC curve analysis showed that the area under the predicted ROC curve of NLR and PLR for atherosclerotic plaque in acute cerebral infarction was 0.845 and 0.742,respectively.Conclusion The high expression of NLR and PLR in patients with acute cerebral infarction may be related to the formation of carotid atherosclerotic plaque.The increase of NLR and PLR has certain value in predicting the formation of carotid atherosclerotic plaque in patients with acute cerebral infarction.
作者
陶飞
赵旺
琚双五
TAO Fei;ZHAO Wang;JU Shuang-wu(Department of Neurology,Chizhou People's Hospital,Chizhou Anhui 247100,China)
出处
《临床和实验医学杂志》
2021年第6期606-609,共4页
Journal of Clinical and Experimental Medicine
基金
安徽省自然科学基金项目(编号:1508075SQH226)。
