摘要
冠状动脉疾病(coronary artery disease,CAD)也称为动脉硬化症,它是因脂肪斑块在心血管内积聚而引起的疾病,心脏动脉的粥样硬化是其潜在致病原因。研究发现多种血液标志物与CAD的风险增加相关,其中微小RNA(microRNA,miRNA)是一类小的非编码核糖核酸分子,长度约为20-22 bp,在心脏和血管发育以及心脏病理生理中起着关键作用,并在血浆和其他体液中相对稳定,因此可以用作心源性疾病的生物标志物。文章就CAD中miRNA的最新研究进展及分子机制进行综述。
Coronary artery disease(CAD)is also known as arteriosclerosis.It is a disease caused by the accumulation of fatty plaques in the cardiovascular system.The atherosclerosis of the heart artery is the potential cause of the disease.Studies have found that a variety of blood markers are associated with the increased risk of CAD.Among them,MicroRNA(miRNA)is a kind of small non-coding ribonuclease acid molecule with a length of about 20-22 bp.It plays a key role in heart and vascular development and cardiac pathophysiology.miRNA is relatively stable in plasma and other body fluids,so it can be used as a biomarker for cardiogenic diseases.This review summarized the latest research progress and the molecular mechanism of miRNA in CAD.
作者
臧允慧
黄立娟
Zang Yunhui;Huang Lijuan(Department of Clinical Laboratory,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)
出处
《国际免疫学杂志》
CAS
2021年第1期110-113,共4页
International Journal of Immunology
