摘要
股骨头坏死是一种由多种因素造成的较为严重的骨科疾病,临床上难以治愈,预后较差,严重威胁人类健康。该病发病机制尚不清楚。不同原因引起的股骨头坏死涉及了体内多种代谢途径的紊乱。骨代谢相关信号通路异常转导造成的来源于骨髓的间充质干细胞异常增殖分化、骨代谢平衡失调、骨小梁破坏增加可能是引起股骨头坏死的重要原因。骨髓间充质干细胞是一种具有自我更新和多向分化能力的多潜能干细胞,有良好的再生率,提高骨髓间充质干细胞的成骨分化能力是抑制骨吸收、促进骨基质重建的关键,对骨骼的重塑具有重要作用。近年来中国传统中医药在预防和治疗股骨头坏死方面的研究较多,并发现多种单味中药、中药单体及中药复方可以通过靶向信号分子调控骨髓间充质干细胞分化方向和分化进程,具有巨大的骨缺损修复潜力,可发挥抗股骨头坏死的活性。中医药通过调控骨代谢相关信号通路预防和治疗股骨头坏死已成为了时下研究热点。现通过对中医药防治股骨头坏死的作用机制及相关信号转导通路等研究进展进行综述,探究缓解骨丢失速率、促进骨形成、修复骨缺损的部分机制,旨在为中医药防治股骨头坏死的深入研究提供参考。在临床方面的相关应用研究也为股骨头坏死的基因辅助性治疗提供特异性靶点。
Osteonecrosis of the femoral head(ONFH)is a serious orthopedic disease caused by many factors. It is difficult to cure clinically and has a poor prognosis,which poses a serious threat to human health.The pathogenesis of this disease is still unclear. The ONFH caused by different causes involves the disorder of a variety of metabolic pathways in vivo. Abnormal proliferation and differentiation of bone mesenchymal stem cells(BMSCs), imbalance of bone metabolism, and increased destruction of bone trabeculae caused by abnormal transduction of bone metabolism-related signaling pathways may be the important causes of ONFH.BMSCs are pluripotent stem cells with self-renewal and multidirectional differentiation ability,which have good regeneration rate. Improving the osteogenic and differentiation ability of BMSCs is the key to inhibit bone absorption and promote bone matrix reconstruction,which plays an important role in bone remodeling. In recent years,there are many studies on the prevention and treatment of ONFH in traditional Chinese medicine(TCM),and it has been found that a variety of single herbs,monomers and compounds can regulate the differentiation direction and process of BMSCs by targeting signal molecules,with great potential for bone defect repair and anti-femoral head necrosis activity. Nowadays, prevention and treatment of ONFH by regulating bone metabolism signaling pathways has become a hot research topic. In this paper,the mechanism and related signal transduction pathways of TCM in preventing and treating ONFH were reviewed to explore some mechanisms of alleviating the rate of bone loss,promoting bone formation,and repairing bone defects,so as to provide reference for further research on the prevention and treatment of ONFH by TCM. The related clinical application studies also provided specific targets for gene-assisted therapy of ONFH.
作者
黄荣兰
胡文彬
詹庆昊
HUANG Rong-lan;HU Wen-bin;ZHAN Qing-hao(Graduate School,Anhui University of Chinese Medicine,Hefei 230012,China;Affiliated Hospital of Institute of Neurology,Anhui University of Chinese Medicine,Hefei 230061,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第8期241-250,共10页
Chinese Journal of Experimental Traditional Medical Formulae
基金
安徽中医药大学科研基金项目(2020sjzd06)。
关键词
股骨头坏死
中医药
信号通路
骨髓间充质干细胞
研究进展
osteonecrosis of the femoral head
traditional Chinese medicine
signaling pathways
bone mesenchymal stem cells
review
