摘要
目的探讨同步放化疗与单纯放疗治疗复发性宫颈癌的疗效及安全性。方法将260例复发性宫颈癌患者依据治疗方式不同分为同步放化疗组(150例)和单纯放疗组(110例),单纯放疗组予以放疗,同步放化疗组在单纯放疗组的治疗基础上予以同步化疗。比较两组患者临床疗效、血清肿瘤标志物[鳞状细胞癌相关抗原(SCC-Ag)、癌胚抗原(CEA)、糖类抗原72-4(CA72-4)]水平、不良反应及生存情况。结果同步放化疗组患者治疗有效率为90.00%(135/150),明显高于单纯放疗组的71.82%(79/110),差异有统计学意义(P﹤0.01)。治疗前,两组患者SCC-Ag、CEA及CA72-4水平比较,差异均无统计学意义(P﹥0.05);治疗后,两组患者SCC-Ag、CEA及CA72-4水平均降低(P﹤0.05),且同步放化疗组患者SCC-Ag、CEA及CA72-4水平均明显低于单纯放疗组(P﹤0.01)。两组患者3~4级不良反应总发生率比较,差异无统计学意义(P﹥0.05)。同步放化疗组患者3年生存率及5年生存率均明显高于单纯放疗组,差异均有统计学意义(P﹤0.01)。结论同步放化疗相较于单纯放疗治疗复发性宫颈癌具有更加显著的疗效,可降低血清肿瘤标志物水平,提高生存率,且不会明显增加不良反应。
Objective To investigate the effect and safety of concurrent chemoradiotherapy and radiotherapy alone in the treatment of recurrent cervical cancer.Method A total of 260 patients with recurrent cervical cancer were divided into a concurrent chemoradiotherapy group(150 cases)and a radiotherapy alone group(110 cases)according to different treatment methods.The radiotherapy alone group received radiotherapy,and the concurrent chemoradiotherapy group received concurrent chemotherapy based on the treatment of the radiotherapy alone group.The clinical efficacy,serum tumor markers[squamous cell carcinoma associated antigen(SCC-Ag),carcinoembryonic antigen(CEA),carbohydrate antigen 72-4(CA72-4)]levels,adverse events,and overall survival were compared between the two groups of patients.Result The clinical effectiveness rate of patients in the concurrent chemoradiotherapy group was 90.00%(135/150),which was significantly higher than 71.82%(79/110)in the radiotherapy alone group,the difference was statistically significant(P<0.01).Before treatment,there were no significant differences in the levels of SCC-Ag,CEA,and CA72-4 between the two groups of patients(P>0.05).After treatment,the levels of SCC-Ag,CEA,and CA72-4 in the two groups decreased(P<0.05),and the levels of SCC-Ag,CEA,and CA72-4 in the concurrent chemoradiotherapy group were significantly lower than those in the radiotherapy alone group(P<0.01).There was no significant difference in the incidence of 3-4 grade adverse events between the two groups of patients(P>0.05).The 3-year overall survival rate and 5-year overall survival rate of patients in the concurrent chemoradiotherapy group were significantly higher than those in the radiotherapy alone group,and the differences were statistically significant(P<0.01).Conclusion Concurrent chemoradiotherapy has a more remarkable effect in treating recurrent cervical cancer than radiotherapy alone.The concurrent regimen could reduce serum tumor markers’level and prolong survival without significantly increasing the risk of adverse events.
作者
刘金阳
权丽丽
LIU Jinyang;QUAN Lili(Department of Obstetrics Clinic,Sanmenxia Central Hospital,Sanmenxia 472000,He’nan,China;Department of Obstetrics and Gynecology,Sanmenxia Central Hospital,Sanmenxia 472000,He’nan,China)
出处
《癌症进展》
2021年第7期737-740,共4页
Oncology Progress
关键词
同步放化疗
单纯放疗
复发性宫颈癌
疗效
concurrent chemoradiotherapy
radiotherapy alone
recurrent cervical cancer
effect
