摘要
2型糖尿病是由多种因素导致的胰岛β-细胞功能障碍和(或)胰岛素敏感性降低的一种内分泌紊乱性疾病。WNT信号转录因子TCFL2是迄今为止对疾病易感性影响最大的T2DM相关基因。然而,TCF7L2基因变异增加T2DM风险的具体机制仍不清楚。在这篇综述中,首先回顾了近几年关于TCF7L2在不同种族人群中与T2DM的遗传风险相关性和TCF7L2与T2DM、肥胖等的相关代谢特征的研究。其次,探讨了TCF7L2基因变异在胰腺β-细胞功能障碍和外周组织胰岛素抵抗增加的最新研究进展和存在争议。为T2DM进一步的前瞻性研究提供新思路新方向,以便增加对特定糖尿病表型和基因型的了解,实现早期发现可预防或延迟并发症,从而降低发病率和死亡率。
Type 2 diabetes is an endocrine disorder with multiple causes of islet-cell dysfunction and/or reduced insulin sensitivity.The WNT signal transcription factor TCFL2 is the T2 DM-related gene that has the greatest impact on disease susceptibility so far.However,the specific mechanism by which TCF7 L2 gene mutation increases the risk of T2 DM is still unclear.In this review,we first reviewed recent researches on the genetic risk correlation of TCF7 L2 with T2 DM in different ethnic populations and the related metabolic characteristics of T2 DM and obesity with TCF7 L2.Secondly,the latest research progress and controversy of TCF7 L2 gene mutation in pancreaticβ-cell dysfunction and increased insulin resistance in peripheral tissue were discussed.To provide new ideas and directions for further prospective study of T2 DM,so as to increase understanding of specific diabetes phenotypes and genotypes,and to achieve early detection to prevent or delay complications,thereby reducing incidence rate and mortality.
作者
王静
乌云娜
WANG Jing;Wuyunna(Inner Mongolia Medical University Huhehot First Hospital,Hohhot 010110 China;Department of Laboratory,The First People's Hospital of Hohhot,Hohhot 010010 China)
出处
《内蒙古医学杂志》
2021年第3期306-309,312,共5页
Inner Mongolia Medical Journal
关键词
2型糖尿病
转录因子7类似物2
单核苷酸多态性
type 2 diabetes mellitus
transcription factor 7 like 2
single nucleotide polymorphisms
