摘要
噬血细胞性淋巴组织细胞增多症(Hemophagocytic lymphohistiocytosis,HLH)是一种以免疫系统过度激活,导致炎性细胞因子分泌过多为特征的综合征。患者通常表现为高热、细胞减少、高铁蛋白血症和肝脾肿大。其疾病过程从轻度到致命的多器官衰竭不等,该病进展迅速,且容易误诊,病死率高。对该疾病的早期认识和及时诊治有助于预防致命的后果。现行的HLH诊治中国专家共识中,对于最后2个标准[即sIL-2受体和自然杀伤(natural killer,NK)细胞活性]的测定,流式细胞术发挥着重要作用。近年来,利用流式细胞术检测潜在生物标志物为HLH的诊断开辟了新的途径。本综述将围绕流式细胞术在其中的应用展开对该疾病的一些思考。
Hemophagocytic lymphohistiocytosis(HLH)is a syndrome characterized by excessive secretion of inflammatory cytokines due to excessive activation of the immune system.Patients usually present hyperpyrexia,cell loss,methemoglobinemia and hepatosplenomegaly.The course of the disease ranges from mild to fatal multiple organ failure.With high mortality,the disease progresses rapidly and is easily misdiagnosed.Early recognition and timely diagnosis and treatment of the disease are helpful to prevent fatal consequences.In the current consensus of Chinese experts on HLH diagnosis and treatment,flow cytometry plays an important role in the determination of the last two criteria[sIL-2 receptor and natural killer(NK)cell activity].In recent years,the detection of potential biomarkers by flow cytometry has opened up a new way for the diagnosis of HLH.This review will focus on the application of flow cytometry to the disease.
作者
杨雨宇
杨金荣(综述)
曾云
武坤(审校)
YANG Yuyu;YANG Jinrong;ZENG Yun;WU Kun(Department of Hematology,First Affiliated Hospital of Kunming Medical University/Yunnan Blood Disease Research Center,Kunming 650032,China)
出处
《临床与病理杂志》
CAS
2021年第4期942-947,共6页
Journal of Clinical and Pathological Research
基金
云南省教育厅科学研究基金(2020J0172)。
