摘要
目的探讨叶酸受体-α(FR-α)、Ki-67蛋白在不同宫颈组织中的表达差异及在宫颈癌组织中的临床意义。方法选择2018年1月至2019年12月本院收治的429例宫颈组织异常患者,按照疾病类型将其分为慢性宫颈炎组(154例)、宫颈上皮内瘤变组(140例)、宫颈癌组(135例),并选择同期140例宫颈组织无异常者作为对照组。比较各组宫颈组织、不同程度宫颈病变、不同临床分期宫颈癌组织中FR-α和Ki-67蛋白表达差异,并分析FR-α和Ki-67蛋白表达的相关性。结果对照组、慢性宫颈炎组、宫颈上皮内瘤变组和宫颈癌组宫颈组织中FR-α、Ki-67蛋白表达阳性率呈逐渐增加趋势,四组宫颈组织FR-α、Ki-67蛋白表达阳性率和表达强度比较,差异具有统计学意义(P<0.05)。随着宫颈上皮内瘤变病变程度加重和宫颈癌临床分期增加,FR-α、Ki-67蛋白表达强阳性率明显增加(P<0.05)。Spearman相关性分析结果显示,宫颈组织中FR-α、Ki-67蛋白表达具有正相关性(r=0.692,P<0.05)。结论宫颈组织中FR-α与Ki-67蛋白阳性表达与宫颈病变疾病有关,可能是宫颈癌发生、进展的促进因素。
Objective To investigate the expression difference of folate receptor-α(FR-α)and Ki-67 protein in different cervical tissues and its clinical significance in cervical cancer.Methods A total of 429 patients with cervical tissue abnormalities admitted in our hospital from January 2018 to December 2019 were selected,and the patients were divided into chronic cervicitis group(154 cases),cervical intraepithelial neoplasia group(140 cases)and cervical cancer group(135 cases)according to disease types,and 140 patients with no cervical tissue abnormalities at the same period were selected as control group.The differences in the expression of FR-αand Ki-67 proteins in cervical tissues,different degrees of cervical lesions and different clinical stages of cervical cancer were compared among the groups,and the correlation between FR-αand Ki-67 protein expression was analyzed.Results The positive rates of FR-αand Ki-67 protein expression in cervical tissues of the control group,chronic cervicitis group,cervical intraepithelial neoplasia group and cervical cancer group gradually increased,and the differences in the positive rates and expression intensity of FR-αand Ki-67 protein expression in cervical tissues of the four groups were statistically significant(P<0.05).With the aggravation of cervical intraepithelial neoplasia and the increase of clinical stage of cervical cancer,the strong positive rate of FR-αand Ki-67 protein expression increased significantly(P<0.05).Spearman correlation analysis result showed that there was a positive correlation between the expression of FR-αand Ki-67 in cervical tissue(r=0.692,P<0.05).Conclusion The positive expression of FR-αand Ki-67 protein in cervical tissue is related to cervical diseases,which may be the promoting factor in the occurrence and progression of cervical cancer.
作者
钟璧璟
邹娜
吴敏
ZHONG Bijing;ZOU Na;WU Min(Pathology Department,Ankang Hospital of Traditional Chinese Medicine,Ankang 725000,China;Gynecology Department,Ankang Hospital of Traditional Chinese Medicine,Ankang 725000,China)
出处
《临床医学研究与实践》
2021年第13期104-107,共4页
Clinical Research and Practice
