摘要
牙周疾病常造成牙槽骨缺损,临床上主要采用自体骨移植或骨替代材料植入治疗。但是现有治疗方法存在诸多缺陷,如供体短缺,移植后骨吸收、感染、出血等。口腔组织是干细胞的重要来源之一,口腔来源干细胞可促进血管及牙周组织再生,近年来已成为牙周疾病再生治疗研究的热点。然而,影响干细胞治疗牙周疾病疗效的因素较多且不易控制。以往的研究主要集中在干细胞自身的治疗作用及其机制探索,较少研究受体或供体微环境与干细胞的相互作用,以及如何建立最佳的治疗策略。该文主要总结了干细胞诱导牙周组织再生的微环境调控机制,并从机体激素水平、代谢状态及免疫调节等方面阐述了微环境对干细胞功能、生物学行为及疗效的影响,旨在加深对干细胞治疗时微环境调控的认识,优化并构建更有效的牙周疾病治疗策略。
Periodontal diseases often cause alveolar bone defects,and clinically,autologous bone graft or bone substitute implantation is mainly used for treatment.However,there are many defects in the existing treatment methods,such as shortage of donors,bone resorption,infection,and bleeding after transplantation.Oral tissue is one of the important sources of stem cells.Oralderived stem cells can promote the regeneration of blood vessels and periodontal tissues,and has become a research hot-spot recent years in the treatment of periodontal diseases.However,there are many factors that affect the efficacy of stem cells in treatment of periodontal diseases and are not easy to control.In the past,researchers mainly focused on the therapeutic effects and mechanisms of stem cells themselves,and seldom studied the interaction between the recipient or donor microenvironment and stem cells,and how to establish the best therapeutic strategy.The microenvironmental regulation mechanism of periodontal tissue regeneration induced by stem cells has been summarized in present paper,and the influence of the microenvironment on the function,biological behavior and curative effect of stem cells have been expounded from the aspects of hormone levels,metabolic status and immune regulation,so to deepen researchers'understanding of microenvironmental regulation during stem cell therapy,and optimize and construct more effective periodontal disease treatment strategies.
作者
杨艳兰
徐普
Yang Yan-Lan;Xu Pu(Department of Implant,Hainan Provincial Center for Stomatology/Dental Center of Haikou Hospital Affiliated to Xiangya Medical College of Central South University,Haikou 570208,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2021年第4期404-409,共6页
Medical Journal of Chinese People's Liberation Army
基金
海南省重点研发计划(ZDYF2016018)。
关键词
微环境
干细胞
牙槽骨缺损
再生治疗
microenvironment
stem cells
periodontal disease
regeneration therapy
