摘要
目的探讨右美托咪定对胸腔镜下肺癌根治术后患者血清炎症因子水平与肺部感染发生情况的影响。方法将205例行胸腔镜下肺癌根治术的患者随机分为观察组102例和对照组103例。观察组与对照组分别采用右美托咪定和依托咪酯进行术中麻醉和术后镇痛。观察两组患者术前、术后6 h、1 d、3 d、7 d血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6水平的变化,以及患者术后的肺部感染情况。结果两组患者的血清IL-6、TNF-α水平比较,差异均有统计学意义(均P<0.05),两组的血清IL-6、TNF-α水平均有随时间变化的趋势(均P<0.05),分组与时间均有交互效应(均P<0.05);其中术前两组IL-6、TNF-α水平差异无统计学意义(P>0.05),但术后各时点观察组的血清IL-6、TNF-α水平均低于对照组(均P<0.05)。观察组患者术后肺部感染发生率低于对照组(P<0.05)。结论右美托咪定可以抑制胸腔镜下肺癌根治术后患者血清炎症因子的产生,并减少术后肺部感染的发生。
Objective To investigate the effect of dexmedetomidine on serum inflammatory factors levels and incidence of pulmonary infection in patients after thoracoscopic radical surgery for lung cancer.Methods A total of 205 patients with lung cancer undergoing thoracoscopic radical surgery were randomly divided into observation group(102 cases)and control group(103 cases).The observation group and the control group were given dexmedetomidine and etomidate respectively for intraoperative anesthesia and postoperative analgesia.An observation was conducted on changes in the levels of serum tumor necrosis factor(TNF)-αand interleukin(IL)-6 in the two groups before operation,six hours after operation,and one,three and seven days after operation,as well as the incidence of postoperative pulmonary infection.Results There were statistically significant differences in serum levels of IL-6 and TNF-αbetween the two groups(all P<0.05),serum IL-6 and TNF-αlevels presented a time-dependent trend in both groups(all P<0.05),and an interactive effect was observed between group and time(all P<0.05);there was no statistically significant difference in preoperative IL-6 or TNF-αlevel between the two groups(P>0.05),but the observation group yielded lower serum IL-6 and TNF-αlevels at each time point postoperatively than the control group(all P<0.05).The incidence rate of postoperative pulmonary infection in the observation group was lower than that in the control group(P<0.05).Conclusion Dexmedetomidine can inhibit the production of serum inflammatory factors and reduce the incidence of postoperative pulmonary infection in patients after thoracoscopic radical surgery for lung cancer.
作者
郭盟迪
张璇
寇立华
杨木泽
GUO Meng-di;ZHANG Xuan;KOU Li-hua;YANG Mu-ze(Department of Anesthesiology,Daxing District People′s Hospital,Beijing 102600,China;Department of Anesthesiology,Chinese People′s Liberation Army General Hospital,Beijing 100036,China)
出处
《广西医学》
CAS
2021年第5期534-536,共3页
Guangxi Medical Journal
基金
北京市卫计委科研项目(201701026)。
关键词
右美托咪定
胸腔镜
肺癌根治术
炎症因子
肺部感染
Dexmedetomidine
Thoracoscope
Radical surgery for lung cancer
Inflammatory factor
Pulmonary infection
