摘要
目的:探讨同步放化疗治疗中晚期直肠癌疗效及对肿瘤细胞Bax、Ki-67表达的影响。方法:选择60例中晚期直肠癌患者作为研究对象,根据随机信封抽签原则把患者分为研究组与对照组各30例。对照组给予化疗治疗,研究组给予同步放化疗治疗,记录随访结果,检测肿瘤细胞Bax、Ki-67表达变化情况。结果:治疗后研究组的总有效率为90.0%,高于对照组的66.7%(P<0.05)。两组治疗期间的血小板减少、粒细胞减少、肝肾功能异常等血液毒性反应对比差异均无统计学意义(均P>0.05)。两组治疗后的促凋亡蛋白Bax表达阳性率高于治疗前(P<0.05),Ki-67表达阳性率低于治疗前(P<0.05)。随访到2021年1月,研究组的中位生存时间与总生存时间均高于对照组(均P<0.05)。结论:同步放化疗治疗中晚期直肠癌患者能促进肿瘤细胞凋亡,抑制Ki-67表达,不会增加血液毒性反应的发生,促进提高治疗效果与延长生存时间。
Objective:To investigate the curative effect of concurrent chemoradiotherapy in the treatment of rectal cancer and its influence on the expression of Bax and Ki-67 in tumor cells.Methods:60 patients with advanced rectal cancer were randomly divided into study group and control group,30 cases in each group.The control group was treated with chemotherapy,while the study group was treated with concurrent chemoradiotherapy.The therapeutic effect was recorded and followed up,the expression changes of Bax and Ki-67 in tumor cells were detected.Results:After treatment,the total effective rate of the study group was 90.0%,which was higher than 66.7%of the control group(P<0.05).There was no statistically significant difference in blood toxic reactions such as thrombocytopenia,neutropenia,liver and kidney dysfunction between the two groups during treatment(all P>0.05).After treatment,the positive rate of pro-apoptotic protein Bax expression in the two groups was higher than that before treatment(P<0.05),and the positive rate of Ki-67 expression in the two groups was lower than that before treatment(P<0.05).Follow up to January 2021,the median survival time and overall survival time of the study group were more than those of the control group(both P<0.05).Conclusion:The application of concurrent chemoradiotherapy in the treatment of patients with rectal cancer can promote tumor cell apoptosis,inhibit Ki-67 expression,and will not increase the occurrence of hematotoxicity,promote the improvement of treatment effect and prolong the survival time.
作者
徐军
白劼
XU Jun;BAI Jie(Department of Oncology,215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China)
出处
《陕西医学杂志》
CAS
2021年第5期587-589,602,共4页
Shaanxi Medical Journal
