摘要
目的:探讨帕利哌酮联合奥氮平对首发双相情感障碍(BD)患者疗效及血清同型半胱氨酸(Hcy)水平的影响。方法:选择本院于2018年9月—2020年9月首发BD患者82例,以随机表法分为观察组与对照组各41例。对照组口服奥氮平片,起始剂量10 mg/d,1周内逐渐增加剂量至15~20 mg/d,1次/d;观察组在对照组基础上联用帕利哌酮缓释片,起始剂量6 mg/d,2周后根据病情调整剂量至9~12 mg/d,1次/d。两组疗程均为6周。比较两组首发BD患者治疗6周总有效率、治疗前与治疗6周Bech-Rafaelsen躁狂量表(BRMS)评分和临床总体印象疾病严重度量表-双相情感版(CGI-BP)评分、言语记忆测验(HVLT-R)和持续操作测验(CPT)评分、血清Hcy水平及不良反应量表(TESS)评分。结果:观察组首发BD患者治疗6周总有效率高于对照组(P<0.05)。两组首发BD患者治疗前BRMS评分和CGI-BP评分比较无显著性差异(P>0.05);治疗6周BRMS评分和CGI-BP评分均低于治疗前(P<0.05);观察组治疗6周BRMS评分和CGI-BP评分低于对照组(P<0.05)。两组首发BD患者治疗前HVLT-R评分和CPT评分比较无显著性差异(P>0.05);治疗6周HVLT-R评分和CPT评分高于治疗前(P<0.05);观察组治疗6周HVLT-R评分和CPT评分高于对照组(P<0.05)。两组首发BD患者治疗前血清Hcy水平比较无显著性差异(P>0.05);治疗6周血清Hcy水平低于治疗前(P<0.05);观察组治疗6周血清Hcy水平低于对照组(P<0.05)。两组首发BD患者治疗3周和治疗6周TESS评分比较无显著性差异(P>0.05)。结论:帕利哌酮联合奥氮平对首发BD患者疗效显著,且可降低患者血清Hcy水平。
Objective:To investigate the effect of paliperidone combined with olanzapine on first-episode bipolar disorder(BD)and serum homocysteine(Hcy).Methods:A total of 82 patients with BD in our hospital from September 2018 to September 2020 were randomly divided into observation group and control group,41 cases in each group.The control group took olanzapine tablets orally with the initial dose of 10 mg/day,and the dose was gradually increased to 15~20 mg per day within one week.The observation group was treated with paliperidone sustained-release tablets on the basis of the control group,and the initial dose was 6 mg/day.Two weeks later,according to the patient's condition,the dose was adjusted to 9~12 mg/day.The treatment course of both groups was six weeks.The total effective rate of first-episode BD patients in both groups was compared after six weeks of treatment.Before treatment and six weeks after treatment,Bech rafaelsen mania scale(BRMS)score,clinical global impression disease severity scale-bipolar disorder version(CGI-BP)score,verbal memory test(HVLT-R)score,continuous operation test(CPT)score,serum Hcy level,and adverse reaction scale(TESS)score were measured.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).There was no significant difference in BRMS score and CGI-BP score between the two groups before treatment(P>0.05).The BRMS score and CGI-BP score of six weeks after treatment were lower than those before treatment(P<0.05).There was no significant difference in HVLT-R score and CRT score between the two groups before treatment(P>0.05).Six weeks after treatment,the HVLT-R score and CRT score in both groups were higher than those before treatment,and these two scores in the observation group were higher than those in the control group after six weeks of treatment(P<0.05).There was no significant difference in serum Hcy level between the two groups before treatment(P>0.05).The serum Hcy level at six weeks after treatment was lower than that before treatment(P<0.05),and the serum Hcy level in the observation group was lower than that in the control group after six weeks(P<0.05).There was no significant difference in TESS score between the two groups after three weeks and six weeks of treatment(P>0.05).Conclusion:Paliperidone combined olanzapine has a significant effect on first-episode BD patients and can reduce the serum Hcy level.
作者
段肖玲
Duan Xiaoling(Brain Hospital Affiliated to Guangzhou Medical University,Guangdong510370)
出处
《天津药学》
2021年第2期28-30,共3页
Tianjin Pharmacy
