摘要
肠道分节丝状菌(Segmented filamentous bacteria,SFB)为肠道共生菌,借助钩状突起与肠上皮细胞(Intestinal Epithelial Cells,IECs)紧密结合的独特黏附方式,在刺激宿主肠道免疫成熟、防御病原菌感染及维持肠道稳态等方面发挥重要作用。因此,本文通过SFB定植后与肠内辅助性T 17(T Helper 17,Th17)细胞、IgA^(+)B细胞及固有淋巴细胞(Innate Lymphoid Cells,ILCs)的互作影响宿主肠黏膜免疫系统,并对SFB在模式动物中的研究现状进行综述,以期为SFB调控肠道免疫、治疗动物疾病、保障机体健康提供思路。
Intestinal Segmented filamentous bacteria(SFB),as intestinal symbiosis bacteria,played an important role in stimulating intestinal immune maturation,defending against pathogenic bacteria infection and maintain intestinal homeostasis,etc.by virtue of the unique adhesion mode of close combination of hooklike processes and intestinal epithelial cells(IECs).Therefore,the host intestinal mucosal immune system was affected by the interaction of SFB with T helper 17(Th17)cells,IgA^(+)B cells and innate lymphocyte cells(ILCs),the research status of SFB in model animals was summarized,so as to provide ideas and perspectives for SFB to regulate intestinal immunity and treat animal diseases to protect the body’s health.
作者
钟奇祺
张海波
黎力之
廖晓鹏
关玮琨
郭冬生
ZHONG Qiqi;ZHANG Haibo;LI Lizhi;LIAO Xiaopeng;GUAN Weikun;GUO Dongsheng(College of Life Science and Resources and Environment,Yichun University,Engineering Technology Research Center of Jiangxi Universities and Colleges for Selenium Agriculture,Yichun Key Laboratory of Functional Agriculture and Ecological Environment,Jiangxi Yichun 336000,China;School of Continuing Education,Yichun University,Jiangxi Yichun 336000,China)
出处
《中国畜牧杂志》
CAS
北大核心
2021年第5期17-22,共6页
Chinese Journal of Animal Science
基金
国家地区科学基金项目(32060773)
江西省自然科学基金(20202BABL205010)
江西省现代农业产业技术体系建设专项资金(JXARS-14)
宜春学院科研发展基金项目(ky fzl2020008)
江西省教育厅项目(GJJ190848)。
