摘要
嗅觉结合蛋白是嗅觉系统的第一个参与者,主要表达在嗅觉外周系统淋巴液中,负责识别、结合和转运气味和信息素分子到达嗅觉受体。近些年,随着各种生物新技术的应用,大量昆虫嗅觉结合蛋白被鉴定出来,其各种不同功能得到揭示。本文对近年来嗅觉结合蛋白的分子特征、蛋白结构、功能和应用等方面的研究进展进行总结和综述。总的来说,嗅觉结合蛋白包括气味结合蛋白(odorant-binding proteins,OBPs)、化学感受蛋白(chemosensory proteins,CSPs)和尼曼-匹克C2型蛋白(Niemann-Pick type C2 proteins,NPC2)三大家族,在α-螺旋和β-折叠的基础上形成了相对简单而稳定的球形结构,使它们能适应各种环境和任务,所以嗅觉结合蛋白蛋白具有复杂多样的功能,且这些功能对昆虫生理和行为尤为重要。基于嗅觉结合蛋白功能,研究者已经把它们应用于生物防治、品种选育和制作生物嗅觉传感器等,具有巨大的潜在价值。本综述为昆虫嗅觉结合蛋白后续研究提供了参考信息及一些新的思路。
As the first participant in the olfactory system,olfactory binding proteins are mainly expressed in the hemolymph of peripheral olfactory system and play roles in recognizing,binding and transporting odors or pheromones to odor receptors.In recent years,with the application of novel modern biological technology,more olfactory binding proteins have been identified,and their diverse functions have been revealed.In this article,we summarized the research progress in the molecular characteristics,structure,functions and application of olfactory binding proteins in recent years.Generally,olfactory binding proteins are classified into three families,odorant-binding proteins(OBPs),chemosensory proteins(CSPs)and Niemann-Pick type C2 proteins(NPC2).Based on the α-helix and β-sheet,olfactory binding proteins form stable globular structure,which is beneficial for them to adapt to a variety of environments and tasks.And diverse functions of olfactory binding proteins are particularly important for insect physiology and behavior.Nowadays,olfactory binding proteins are used in biological control,variety selection and breeding,biosensor making,and so on.This review provides references and some new ideas for further research on olfactory binding proteins in insects.
作者
吴帆
张莉
邱一蕾
李红亮
WU Fan;ZHANG Li;QIU Yi-Lei;LI Hong-Liang(Zhejiang Provincial Key Laboratory of Biometrology and Inspection&Quarantine,College of Life Sciences,China Jiliang University,Hangzhou 310018,China)
出处
《昆虫学报》
CAS
CSCD
北大核心
2021年第4期523-535,共13页
Acta Entomologica Sinica
基金
国家自然科学基金项目(32000331,31772544)
浙江省自然科学基金项目(LQ21C030007)
科技部基础资源调查专项(2018FY100405)。
关键词
昆虫
嗅觉
气味结合蛋白
化学感受蛋白
尼曼-匹克C2型蛋白
蛋白结构
生物防治
Insect
olfaction
odorant-binding proteins
chemosensory proteins
Niemann-Pick type C2 proteins
protein structure
biological control
