摘要
帕金森病的跌倒和步态障碍症状是致残的主要因素,其对药物治疗和丘脑下核刺激的反应通常较差,严重影响患者的生活质量。脚桥核作为中脑运动区和网状激活系统的一部分,与基底神经节、丘脑和小脑等多个脑区均有密切的纤维联系,在姿势和步态的控制中起着重要作用。扩散张量成像和功能磁共振成像可分别反映脑白质纤维束结构和脑区网络功能方面的信息,能更好地评估脚桥核在中轴症状发生中的作用。作者就扩散张量成像和功能磁共振成像在帕金森患者脚桥核网络连接中的研究进行综述。
Falls and gait disorders are the main causes of disability in Parkinson’s disease,and its response to drug therapy and subthalamic stimulation is usually poor,which seriously affect the quality of life.As a part of mesencephalic locomotor region and reticular activating system,the pedunculopontine nucleus is closely connected with the basal ganglia,thalamus,cerebellum and other brain regions,and participates in posture and gait control.Diffusion tensor imaging(DTI)and functional magnetic resonance imaging(fMRI)can reflect the structure of white matter fiber tracts and the function of brain regions,who well assess the role of the pedunculopontine nucleus in postural instability/gait difficulty.This article will review the application of DTI and fMRI in the network connection of the pedunculopontine nucleus in Parkinson’s patients.
作者
冯芹
白岩
陈翰林
张梦焕
王梦珂
王梅云
FENG Qin;BAI Yan;CHEN Hanlin;ZHANG Menghuan;WANG Mengke;WANG Meiyun(Department of Medical Imaging,Zhengzhou University People's Hospital,Henan Province People's Hospital,Zhengzhou 450003,China;Henan Provincial People's Hospital,Henan Key Laboratory of Neurological Imaging,Zhengzhou 450003,China;Fuzhou International Travel Health Care Center,Fuzhou 350001,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2021年第5期96-98,106,共4页
Chinese Journal of Magnetic Resonance Imaging
基金
国家重点研发计划项目(编号:2017YFE0103600)
国家自然科学基金项目(编号:81720108021)
中原千人计划项目(编号:ZYQR201810117)
河南省科技攻关计划项目(编号:182102310496)
河南省医学科技攻关计划项目(编号:2018020403)。
关键词
帕金森病
脚桥核
扩散张量成像
功能磁共振成像
脑网络
Parkinson disease
the pedunculopontine nucleus
diffusion tensor imaging
functional magnetic resonance imaging
brain networks
