摘要
目的:评析冠心病合并快速型心律失常患者在医治过程中使用胺碘酮的临床价值。方法:将2019年11月—2020年11月治疗的156例冠心病合并快速型心律失常患者,随机分为对照组与观察组各78例,前者使用常规治疗,后者加用胺碘酮治疗。评价不同治疗方案的疗效、患者心电图结果差异、不良反应、心功能及血脂指标变化情况。结果:两组用药方案均具有较高的安全性,但观察组患者加用胺碘酮治疗后的总有效率96.15%高于对照组84.62%(χ^(2)=5.974,P<0.05);用药前两组患者心功能指标无明显差异(P>0.05);用药后加用胺碘酮的观察组患者心功能指标恢复效果LVEDD(52.76±4.89)mm、LVESD(36.45±3.65)mm、LVEF(53.35±5.11)%显著优于常规治疗的对照组(t=5.316、8.817、8.050,P<0.05);用药前血脂指标(TG、TC、HDL-C、LDL-C)无明显差异,用药后的观察组血脂调节效果优于对照组(P<0.05);且用药后观察组心率明显低于对照组,P-R间期和Q-T间期持续时间高于对照组(P<0.05)。结论:对冠心病合并快速型心律失常患者治疗时在常规用药基础上运用胺碘酮能够保证合理安全用药同时获得高效的治疗结果,能够有效改善患者心功能、血脂等指标及电生理,证实了胺碘酮对于治疗冠心病合并快速型心律失常的优越性。
Objective:To evaluate the clinical value of amiodarone in the emergency treatment of patients with coronary heart disease and tachyarrhythmia.Methods:156 cases of coronary heart disease patients with tachyarrhythmia treated from November 2019 to November 2020 were randomly divided into control group and observation group,78 cases in each group.The efficacy,ECG results,adverse reactions,cardiac function and blood lipid indexes of different treatment schemes were evaluated.Results:The two groups of medication regimens have high safety,but the total effective rate of 96.15%of the observation group after adding amiodarone is higher than that of the control group 84.62%(χ^(2)=5.974,P<0.05);the first two groups of medication There was no significant difference in the cardiac function indexes of patients(P>0.05);the recovery effect of cardiac function indexes of patients in the observation group with amiodarone after medication was LVEDD(52.76±4.89)mm,LVESD(36.45±3.65)mm,LVEF(53.35±5.11)%was significantly better than the control group using conventional treatment(t=5.316,8.817,8.050,P<0.05);there was no significant difference in blood lipid indexes(TG,TC,HDL-C,LDL-C)before treatment,observation after treatment The blood lipid regulation effect of the group was better than that of the control group(P<0.05);after the comparison of the ECG status of the two groups of patients,the heart rate of the observation group was significantly lower than that of the control group,while the duration of the PR interval and QT interval was higher than that of the control group(P<0.05)).Conclusion:the use of amiodarone in the treatment of patients with coronary heart disease can improve the safety of blood lipid and arrhythmia.
作者
任双玲
薛培举
杨广明
REN Shuangling;XUE Peiju;YANG Guangming(Department of Cardiology,the first people’s Hospital of Xinmi,Zhengzhou,Henan 452370,China)
出处
《中国药物滥用防治杂志》
CAS
2021年第2期188-191,195,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
胺碘酮
冠心病
快速型心律失常
急诊
应用价值
amiodarone
coronary heart disease
tachyarrhythmia
emergency
application value
