摘要
目的探讨血清脑源性神经营养因子(BDNF)、皮质醇(Cor)、去甲肾上腺素(NE)与人乳头瘤病毒(HPV)感染育龄女性抑郁症关联性及疗效预测价值。方法选取2019年1月-2020年2月新乡医学院第二附属医院心境障碍一科收治的HPV感染育龄女性抑郁症患者103例为研究组,另选取同期HPV感染无抑郁症患者103例为对照组。入院后抽取两组患者血液样本测定血清BDNF、Cor、NE水平,比较研究组与对照组、研究组不同病情患者BDNF、Cor、NE水平,分析血清BDNF、Cor、NE水平与HPV感染育龄女性抑郁症患者汉密顿抑郁量表(HAMD)评分的关系,并比较研究组不同疗效患者一般资料与血清各指标水平,探究疗效不良的影响因素,及血清BDNF、Cor、NE对疗效不良的预测价值。结果研究组血清NE、BDNF水平低于对照组,Cor水平高于对照组(P<0.05);HPV感染育龄女性抑郁症患者HAMD评分与血清NE、BDNF水平呈负相关,与血清Cor水平呈正相关(P<0.05);研究组不同疗效患者的血清BDNF、NE、Cor水平、月收入、治疗依从性、与邻里关系存在显著差异(P<0.05);血清BDNF、NE、Cor联合预测HPV感染育龄女性抑郁症疗效不良的曲线下面积(AUC)为0.883,大于各指标单一预测,联合预测的最佳敏感度、特异度分别为86.90%、84.21%。结论血清BDNF、Cor、NE水平与HPV感染育龄女性抑郁症病情密切相关,且在预测疗效方面具有良好应用价值。
OBJECTIVE To explore the correlation between serum brain-derived neurotrophic factor(BDNF), cortisol(Cor), norepinephrine(NE) and depression condition of women with human papillomavirus(HPV) infection at childbearing age and observe the value of the above indexes in prediction of curative effects. METHODS A total of 103 women with HPV infection at childbearing age who were treated in department of mood disorders of the Second Affiliated Hospital of Xinxiang Medical College from Jan 2019 to Feb 2020 were assigned as the study group, meanwhile, 103 HPV infection patients without depression were chosen as the control group.The blood specimens were drawn from the two groups after the admission to hospital so as to detect the levels of serum BDNF, Cor and NE.The levels of BDNF, Cor and NE were compared between the study group and the control group and among the patient with different illness condition in the study group, the correlation between the levels of serum BDNF, Cor and NE and the Hamilton Depression Scale(HAMD) score of the HPV infection women at childbearing age was observed.The baseline data and levels of serum indexes were compared among the patients with different curative effects in the study group, the influencing factors for the adverse curative effects were explored, and the values of serum BDNF, Cor and NE in prediction of adverse curative effects were evaluated. RESULTS The levels of serum NE and BDNF of the study group were significantly lower than those of the control group, the Cor level of the study group was significantly higher than that of the control group(P<0.05).The HAMD score was negatively correlated with the levels of serum NE and BDNF of the HPV infection women at childbearing age and was positively correlated with the serum Cor level(P<0.05).There were significant differences in the levels of serum BDNF, NE and Cor, monthly income, treatment compliance and relationship with neighbors among the patients with different curative effects in the study group(P<0.05).The area under curve(AUC) of the joint detection of serum BDNF, NE and Cor was 0.883 in prediction of adverse curative effects of the HPV infection women at childbearing age, larger than that of the single index;the optimal sensitivity and specificity of the joint detection of the indexes were 86.90% and 84.21%, respectively. CONCLUSION The levels of serum BDNF, Cor and NE are closely associated with the depression condition of the HPV infection women at childbearing age and have high value in prediction of the curative effects.
作者
马敬
岳凌峰
仲照希
李君利
MA Jing;YUE Ling-feng;ZHONG Zhao-xi;LI Junrli(Second Affiliated Hospital of Xinxiang Medical College,Xinxiang,Henan 453000,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2021年第8期1239-1243,共5页
Chinese Journal of Nosocomiology
基金
河南省自然科学基金资助项目(182300410317)
河南省基础与前沿技术研究计划基金资助项目(152300410121)。
关键词
育龄女性
人乳头瘤病毒感染
抑郁症
脑源性神经营养因子
皮质醇
去甲肾上腺素
Women at childbearing age
Human papillomavirus infection
Depression
Brain-derived neurotrophic factor
Cortisol
Norepinephrine
