摘要
特发性膜性肾病是一种自身免疫病,病程长,易发展成为终末期肾病。精准药学摒弃了传统“千人一药”的用药方式,而提倡为患者提供精准、安全、经济的个体化用药方案。本文简要概述了在特发性膜性肾病的治疗中可借助的治疗药物监测、基因检测及群体药动学等基于精准药学的技术手段,为患者的临床合理用药提供参考。
Idiopathic membranous nephropathy is a kind of autoimmune disease.Its duration is long and it is easy to develop into end-stage renal disease.The precision pharmacy abandons the traditional non-individualized medication method and can provide patients with accurate,safe,and economical individualized medication scheme.This paper summarizes some technical means which are based on the precision pharmacy,such as therapeutic drug monitoring,pharmacogenomics and population pharmacokinetics in the treatment of idiopathic membranous nephropathy to provide reference for clinical rational drug use.
作者
付冉
王小楠
丁琮洋
孟璐
董占军
FU Ran;WANG Xiao-nan;DING Cong-yang;MENG Lu;DONG Zhan-jun(Graduate School, Hebei Medical University, Shijiazhuang 050017, Hebei, China;Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050000, Hebei, China)
出处
《中国临床医学》
2021年第2期305-309,共5页
Chinese Journal of Clinical Medicine
基金
2018年度河北省医学科学重点研究计划(20180008).
关键词
精准药学
特发性膜性肾病
治疗药物监测
药物基因组学
群体药动学
precision pharmacy
idiopathic membranous nephropathy
therapeutic drug monitoring
pharmacogenomics
population pharmacokinetics
