摘要
纳米硒作为一种新型单质硒,与有机硒和无机硒相比具有更高的生物利用度,更强的生物活性和更低的毒性,并且具有抗氧化和抗肿瘤的作用。概述了纳米硒在生物医药中的应用,包括纳米硒用于化疗、放疗、放化疗以及其他临床药物的增敏,纳米硒的功能化和靶向修饰增强抗肿瘤效果,含硒纳米材料在抗肿瘤中的应用,纳米硒的毒理学,介绍了纳米硒制剂产业化发展情况。
Nanoselenium, as a new type of elemental selenium, has higher bioavailability, stronger biological activity and lower toxicity than organic selenium and inorganic selenium, and simultaneously has anti-oxidant and anti-tumor effects. This article mainly summarizes the application progress of selenium nanoparticles(Se NPs) in biomedicine, such as chemotherapy,radiotherapy, radio-chemotherapy and other clinical drugs to enhance the sensitization by Se NPs;the functionalization and targeted modification of Se NPs to enhance the anti-tumor effect;Se-nanomaterials in anti-tumor application;the toxicology of Se NPs;and the description of the industrialization research of Se NPs production. The review provides a guidance and support for the future nanoselenium production, study and research integration system.
作者
张泽杭
刘婷
李海伟
桑诚诚
陈义康
陈填烽
ZHANG Zehang;LIU Ting;LI Haiwei;SANG Chengcheng;CHEN Yikang;CHEN Tianfeng(College of Chemistry and Materials Science of Jinan University,Guangzhou 510632,China;Guangdong Jinan Established Selenium Source Nano Technology Research Institute Co.,Ltd.,Guangzhou 510535,China)
出处
《科技导报》
CAS
CSCD
北大核心
2021年第7期48-62,共15页
Science & Technology Review
基金
国家自然科学基金面上项目(21877049)
广州市产业技术重大攻关计划项目(201902020013)。
关键词
纳米硒
肿瘤
精准治疗
selenium nanoparticles
tumour
accurate treatment
