摘要
目的分析甲氨蝶呤联合柳氮磺吡啶和羟氯喹治疗类风湿关节炎的疗效和安全性。方法选取2018年1月至2020年1月我院收治的类风湿关节炎患者40例,根据治疗方法不同分为对照组(n=21)和试验组(n=19)。对照组给予甲氨蝶呤联合来氟米特治疗,试验组给予甲氨蝶呤联合柳氮磺吡啶和羟氯喹治疗。比较两组的临床疗效、炎性指标及不良反应情况。结果试验组的治疗总有效率为94.74%,显著高于对照组的66.67%(P<0.05)。治疗后,试验组的CRP、RF、ESR水平均明显低于对照组(P<0.05)。两组的不良反应发生率比较无统计学差异(P>0.05)。结果甲氨蝶呤联合柳氮磺吡啶和羟氯喹治疗类风湿关节炎疗效显著,可有效降低关节相关炎性指标,且安全性较高,值得临床推广应用。
Objective To analyze the efficacy and safety of methotrexate combined with sulfasalazine and hydroxychloroquine in the treatment of rheumatoid arthritis.Methods 40 cases of patients with rheumatoid arthritis admitted to our hospital from January 2018 to January 2020 were selected and divided into control group(n=21)and experimental group(n=19)according to different treatment methods.The control group was treated with methotrexate combined with leflunomide,and the experimental group was treated with methotrexate combined with sulfasalazine and hydroxychloroquine.The clinical efficacy,inflammatory indicators and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was 94.74%,significantly higher than 66.67%in the control group(P<0.05).After treatment,the CRP,RF and ESR levels of the experimental group were significantly lower than those of the control group(P<0.05).No statistical difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Methotrexate combined with salazosulfopyridine and hydroxychloroquine has significant efficacy in the treatment of rheumatoid arthritis,can effectively improve arthropathy-related inflammatory indicators with higher safety,which is worthy of clinical promotion and application.
作者
胡彦维
HU Yanwei(The People's Hospital of Qingcheng District,Qingyuan 511500,China)
出处
《临床医学工程》
2021年第5期629-630,共2页
Clinical Medicine & Engineering
关键词
甲氨蝶呤
柳氮磺吡啶
羟氯喹
类风湿关节炎
疗效
安全性
Methotrexate
Sulfasalazine
Hydroxychloroquine
Rheumatoid arthritis
Efficacy
Safety
