摘要
目的探讨肺泡灌洗联合乌司他丁对重症肺炎合并急性呼吸窘迫综合征(ARDS)患者血清炎症因子水平的影响。方法选取我院2018年1月至2020年2月收治的52例重症肺炎伴ARDS患者作为研究对象,随机将其分为对照组(26例,肺泡灌洗)和观察组(26例,肺泡灌洗联合乌司他丁)。比较两组患者治疗前、后的血气分析指标、肺功能指标及炎症因子水平。结果治疗后,两组的PaO_(2)、SaO_(2)、FEV1、PEF、MMV均升高,PaCO_(2)、MIP-1α、PCT、HMGB-1、IL-6、CRP及TNF-α水平均降低,且观察组优于对照组(P<0.05)。结论肺泡灌洗联合乌司他丁能有效改善重症肺炎合并ARDS患者的血气分析指标和肺功能指标,降低机体炎症因子水平,值得临床推广应用。
Objective To investigate the effect of alveolar lavage combined with ulinastatin on serum inflammatory factors levels in patients with severe pneumonia complicated with acute respiratory distress syndrome(ARDS).Methods A total of 52 patients with severe pneumonia complicated with ARDS admitted in our hospital from January 2018 to February 2020 were selected as the research objects and randomly divided into control group(26 cases,alveolar lavage)and observation group(26 cases,alveolar lavage combined with ulinastatin).The blood gas analysis indexs,lung function indexs and inflammatory factors levels before and after treatment of the two groups were compared.Results After treatment,PaO_(2),SaO_(2),FEV1,PEF and MMV in the two groups increased,while PaCO_(2),MIP-1α,PCT,HMGB-1,IL-6,CRP and TNF-αlevels decreased,and those in the observation group were better than the control group(P<0.05).Conclusion Alveolar lavage combined with ulinastatin can effectively improve the blood gas analysis indexes and lung function indexes of patients with severe pneumonia complicated with ARDS,and reduce the levels of inflammatory factors,which is worthy of clinical promotion and application.
作者
张怡
徐电
ZHANG Yi;XU Dian(Critical Care Medicine Department,Xianyang Central Hospital,Xianyang 712000;Geriatrics Department,the First Affiliated Hospital of Air Force Military Medical University,Xi'an 710003,China)
出处
《临床医学研究与实践》
2021年第16期89-91,共3页
Clinical Research and Practice
关键词
肺泡灌洗
乌司他丁
重症肺炎
急性呼吸窘迫综合征
alveolar lavage
ulinastatin
severe pneumonia
acute respiratory distress syndrome
