摘要
目的观察柴金饮对痰浊阻肺型慢性阻塞性肺疾病急性加重期(chronic obstructive pulmonary disease with acute exacerbation,AECOPD)患者炎症指标降钙素原(procalcitonin,PCT)、肿瘤坏死因子-α(tumor necrosis factor alpha,TNF-α)及慢性阻塞性肺疾病临床呼吸问卷(clinical COPD questionnaire,CCQ)评分的影响。方法将62例痰浊阻肺型AECOPD患者随机分成两组,每组31例。对照组采用西医常规治疗;治疗组在对照组治疗基础上加用柴金饮口服。两组疗程均为10 d。比较两组患者治疗前后PCT、TNF-α水平,CCQ评分变化以及临床疗效。结果两组患者治疗后PCT、TNF-α水平均较治疗前明显降低(P<0.05),治疗后治疗组PCT、TNF-α水平降低程度显著大于对照组(P<0.05)。与治疗前比较,两组患者治疗后CCQ评分降低(P<0.05),治疗后治疗组CCQ评分降低程度显著大于对照组(P<0.05)。治疗组临床疗效优于对照组(P<0.05)。结论柴金饮能改善痰浊阻肺型AECOPD患者临床症状,减轻炎症反应。
Objective To investigate the effect of Chaijin Decoction on the inflammatory markers of procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)and clinical COPD questionnaire(CCQ)score in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with syndrome of turbid phlegm obstructing the lung.Methods A total of 62 AECOPD patients with syndrome of turbid phlegm obstructing the lung were randomly divided into control group and treatment group,with 31 patients in each group.The patients in the control group were given conventional Western medicine treatment,and those in the treatment group were given oral administration of Chaijin Decoction in addition to the treatment in the control group;the course of treatment was 10 days for both groups.The two groups were compared in terms of the levels of PCT and TNF-αbefore and after treatment,the change in CCQ score,and clinical outcome after treatment.Results After treatment,both groups had significant reductions in the levels of PCT and TNF-α(P<0.05),and the treatment group had significantly greater reductions than the control group(P<0.05).After treatment,both groups had a significant reduction in CCQ score(P<0.05),and the treatment group had a significantly greater reduction than the control group(P<0.05).The treatment group had a significantly better clinical outcome than the control group(P<0.05).Conclusion Chaijin Decoction can improve clinical symptoms and alleviate inflammatory response in AECOPD patients with syndrome of turbid phlegm obstructing the lung.
作者
梁仕勤
刘红宇
叶焰
里自然
刘新宇
高婉玲
LIANG Shi-qin;LIU Hong-yu;YE Yan;LI Zi-ran;LIU Xin-yu;GAO Wan-ling(Department of Pulmonary Diseases,Hospital of Traditional Chinese Medicine Affiliated to Guangzhou Medical University,Guangdong Guangzhou 510130,China)
出处
《安徽中医药大学学报》
CAS
2021年第3期12-16,共5页
Journal of Anhui University of Chinese Medicine
基金
广东省中医药局科研项目(20192074)
广州医科大学附属中医医院“青苗计划”项目(2020B01)。
关键词
慢性阻塞性肺疾病
急性加重期
痰浊阻肺
柴金饮
炎症指标
慢性阻塞性肺疾病临床呼吸问卷
Chronic obstructive pulmonary disease
Acute exacerbation
Syndrome of turbid phlegm obstructing the lung
Chaijin Decoction
Inflammatory marker
Clinical COPD questionnaire
