摘要
中药注射剂疗效确切、临床应用广泛,但是其安全性问题也日益受到关注。中药药代动力学对指导中药注射剂给药方案设计、提高临床用药的安全性和有效性具有重要意义。近年来,随着中药研究思路、技术和方法的进步,研究者对中药注射剂开展了广泛而深入的药代动力学研究,取得了显著的进展。该文对近十年来中药注射剂药代动力学研究进行综述,主要从基于分析技术的临床前体内经时过程、分布、代谢和排泄研究、中药注射剂组分相互作用、疾病状态的影响、中药注射剂与化药相互作用以及中药注射剂临床药代动力学研究这几个方面进行归纳总结,以期为中药注射剂的质量控制、产品开发及临床合理应用等相关研究提供参考。
Traditional Chinese medicine(TCM) injections boast a definite efficacy and have been widely used in clinic. However, the problems in medication safety have been attracted increasing attention. Pharmacokinetics is of significance to guiding TCM injection administration regimen design and improving safety and effectiveness in clinical use. In recent years, with the improvement of ideas, technology and methods of TCM studies, the pharmacokinetic studies of TCM injections have been broadly performed, with a notable progress. This paper reviewed the advance in pharmacokinetics studies of TCM injections in recent ten years, which mainly focused on pre-clinical concentration-time course, distribution, metabolism and excretion in vivo based on analysis techniques, pharmacokinetic interactions of constitutes, impact of pathological state, pharmacokinetic interactions between TCM injection and chemical drugs, and clinical pharmacokinetics studies of TCM injections, in the expectation of providing reference for studies on quality control, product development and rational clinical use of TCM injections.
作者
刘远荣
詹淑玉
郑博鸿
方梦婷
冯一涵
张洁
李明娟
丁宝月
LIU Yuan-rong;ZHAN Shu-yu;ZHENG Bo-hong;FANG Meng-ting;FENG Yi-han;ZHANG Jie;LI Ming-juan;DING Bao-yue(Medical College of Jiaxing University,Jiaxing 314001,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2021年第7期1752-1762,共11页
China Journal of Chinese Materia Medica
基金
浙江省自然科学基金项目(LY18H280011)
国家自然科学基金项目(81503338)
嘉兴市科技计划项目(2020AY10022)
嘉兴学院B类重点建设学科(药学)项目
嘉兴学院重点SRT项目。
关键词
中药注射剂
分析技术
药代动力学
临床药代动力学
药动学相互作用
traditimal Chinese medicine(TCM)injection
analysis technique
pharmacokinetics
clinical pharmacokinetics
pharmacokinetic interactions
